Description

Dabsylaminoethyl Methanethiosulfonate CAS NO 887354-19-0 is a specialized, high-purity biochemical reagent designed for advanced research and synthesis. This compound is a critical building block for the site-specific modification of proteins and peptides, enabling precise bioconjugation and labeling studies. It is essential for researchers and manufacturers in the fields of proteomics, biopharmaceutical development, and diagnostic assay formulation who require reliable, high-quality reagents for their most sensitive applications.

Application

• Site-Directed Protein Labeling: A key reagent for introducing fluorescent or affinity tags at specific cysteine residues in proteins for structural and functional studies.
• Bioconjugation Chemistry: Used in the synthesis of antibody-drug conjugates (ADCs) and other therapeutic bioconjugates, enabling controlled drug-to-antibody ratios.
• Proteomics Research: Facilitates the labeling and enrichment of peptides for mass spectrometry analysis, aiding in protein identification and quantification.
• Diagnostic Reagent Synthesis: Serves as an intermediate in the production of enzyme-linked immunosorbent assay (ELISA) components and other diagnostic tools.
• Crosslinking Agent: Employed to create stable thioether bonds between biomolecules for studying protein-protein interactions.
• Chemical Biology Tool Development: Used to create activity-based probes for monitoring enzyme activity in complex biological systems.

Basic Information

Product Name	Dabsylaminoethyl Methanethiosulfonate
CAS No.	887354-19-0
Molecular Formula	C18H21N3O4S3
Molecular Weight	439.57 g/mol
Synonyms	Dabsylaminoethyl MTS; 2-((4-(Dimethylamino)phenyl)diazenyl)-N-(2-((methylsulfonyl)thio)ethyl)benzenesulfonamide; Dabsyl-AE-MTS; N-Dabsyl-2-aminoethyl methanethiosulfonate; 4-Dimethylaminoazobenzene-4'-sulfonylaminoethyl methanethiosulfonate; DABSYL-AE-MTS; S-(2-((4-(Dimethylamino)phenyl)diazenyl)phenyl)sulfonamido)ethyl methanethiosulfonate
EINECS	Contact for details

Quality Control

Our Dabsylaminoethyl Methanethiosulfonate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to verify identity and purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes. We support compliance with cGMP and ISO 9001 standards for our manufacturing processes.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	Yellow to orange powder or crystalline solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.