Description

5,8-Difluorochroman-4-Amine-Hcl is a high-purity fluorinated chroman derivative, serving as a critical chiral building block in advanced organic synthesis. Its value lies in its unique molecular scaffold, which is essential for constructing complex pharmacophores with potential biological activity. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new drug candidates, particularly in central nervous system (CNS) and cardiovascular therapeutic areas.
• Agrochemical Synthesis: Used in the synthesis of advanced pesticides and herbicides, where the fluorinated chroman structure can enhance biological activity and environmental stability.
• Chemical Research: Serves as a versatile building block in academic and industrial R&D for exploring new chemical spaces and reaction methodologies.
• Ligand and Catalyst Development: Potential precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis.
• Material Science Precursor: Can be utilized in the synthesis of specialty chemicals and advanced materials requiring fluorinated aromatic components.

Basic Information

Product Name	5,8-Difluorochroman-4-Amine-Hcl
CAS No.	886762-85-2
Molecular Formula	C9H10F2NO•HCl
Molecular Weight	221.64 (Free base) / 258.10 (HCl salt)
Synonyms	5,8-Difluoro-3,4-dihydro-2H-1-benzopyran-4-amine hydrochloride; 4-Amino-5,8-difluorochroman hydrochloride; 5,8-Difluorochroman-4-amine hydrochloride; 886762-85-2; 5,8-Difluoro-4-chromanamine HCl; 4-Amino-5,8-difluoro-2H-chromane hydrochloride
EINECS	Contact for details

Quality Control

Our 5,8-Difluorochroman-4-Amine-Hcl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, NMR, and MS for structural confirmation, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.