Description

2,3,4,5,6-Pentafluorophenyl 5-Chloro-2-Methoxybenzenesulphonate is a specialized organofluorine sulfonate ester, a key building block in advanced organic synthesis. This compound is valued for its role as a versatile electrophilic reagent, particularly in the formation of sulfonate esters and as a precursor for more complex fluorinated molecules. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly those requiring fluorinated aromatic systems for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, where the pentafluorophenyl sulfonate group acts as a superior leaving group in nucleophilic substitution reactions.
• Material Science Research: Serves as a precursor for creating specialized monomers or surface-modifying agents aimed at developing polymers with unique fluorinated properties.
• Cross-Coupling Reactions: Functions as an effective electrophile in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to construct complex biaryl systems.
• Chemical Biology Probes: Employed in the design and synthesis of activity-based probes or labeling reagents that target specific biological pathways.
• Ligand and Catalyst Development: Utilized for the modular synthesis of novel ligands and organocatalysts containing sulfonate ester functionalities.

Basic Information

Product Name	2,3,4,5,6-Pentafluorophenyl 5-Chloro-2-Methoxybenzenesulphonate
CAS No.	886361-33-7
Molecular Formula	C13H6ClF5O4S
Molecular Weight	412.69 g/mol
Synonyms	5-Chloro-2-methoxybenzenesulfonic acid 2,3,4,5,6-pentafluorophenyl ester; Pentafluorophenyl 5-chloro-2-methoxybenzenesulfonate; 5-Chloro-2-methoxyphenyl pentafluorophenyl sulfonate; 5-Chloro-2-methoxybenzenesulfonyl pentafluorophenyl ether; 886361-33-7; 5-Chloro-2-methoxybenzenesulphonic acid pentafluorophenyl ester; Pentafluorophenyl 5-chloro-o-anisyl sulfonate
EINECS	Contact for details

Quality Control

Our 2,3,4,5,6-Pentafluorophenyl 5-Chloro-2-Methoxybenzenesulphonate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, essential for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing key parameters such as assay, identity, and impurity profiles. Our quality systems are designed to meet the stringent requirements of research and development and pre-clinical manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.