Description

2,3,4,5,6-Pentafluorophenyl 4-Fluorobenzenesulphonate is a high-value, multi-fluorinated chemical building block used in advanced organic synthesis. Its core value lies in its role as a versatile electrophilic reagent for introducing the pentafluorophenylsulfonyl (Pfp) group, a powerful leaving group in nucleophilic substitution reactions. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for the development of novel active ingredients and complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), especially for fluorinated drug candidates targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides where the introduction of fluorine atoms enhances biological activity and environmental stability.
• Material Science: Serves as a monomer or cross-linking agent in the production of specialty polymers, such as fluorinated polyarylethersulfones, for high-performance membranes and coatings.
• Ligand & Catalyst Development: Employed in the preparation of fluorinated ligands for transition metal catalysis, enabling more efficient and selective synthetic transformations.
• PET (Positron Emission Tomography) Tracer Precursor: Acts as a labeling synthon for introducing fluorine-18 (18F) in radiochemistry for diagnostic imaging agents.
• Organic Synthesis Reagent: A reliable reagent for sulfonylation reactions, facilitating the construction of sulfonate esters under mild conditions in complex molecule synthesis.

Basic Information

Product Name	2,3,4,5,6-Pentafluorophenyl 4-Fluorobenzenesulphonate
CAS No.	885950-58-3
Molecular Formula	C12H4F6O3S
Molecular Weight	342.21 g/mol
Synonyms	4-Fluorobenzenesulfonic Acid 2,3,4,5,6-Pentafluorophenyl Ester; Pentafluorophenyl 4-Fluorobenzenesulfonate; 4-Fluorophenylsulfonyl Pentafluorophenyl Ester; PFBS-Pfp Ester; 4-Fluoro Benzenesulfonyl Pentafluorophenyl Ester; 2,3,4,5,6-Pentafluorophenyl 4-Fluorobenzenesulfonate; Pentafluorophenyl 4-Fluorophenylsulfonate
EINECS	Contact for details

Quality Control

Our 2,3,4,5,6-Pentafluorophenyl 4-Fluorobenzenesulphonate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality systems are designed to support cGMP and ISO 9001 standards for traceability and reliability, making it suitable for pharmaceutical R&D and scale-up.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.