Description

Perfluorophenyl 4-Iodobenzenesulphonate is a high-purity, specialized organofluorine building block and sulfonylation reagent. This compound is critical for introducing the perfluorophenylsulfonyl (PFP-sulfonyl) group, a highly effective leaving group in nucleophilic substitution reactions, particularly in peptide synthesis and pharmaceutical intermediate manufacturing. It is essential for researchers and process chemists in pharmaceutical development, agrochemical synthesis, and advanced materials science who require reliable, high-quality reagents for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate Synthesis: Key reagent for the preparation of sulfonamides and sulfonate esters as active pharmaceutical ingredients (APIs).
• Peptide Chemistry: Used as an activating agent for the synthesis of peptide bonds, especially in solid-phase peptide synthesis (SPPS).
• Agrochemical Development: Building block for creating novel sulfonamide-based herbicides, fungicides, and plant growth regulators.
• Material Science: Intermediate in the synthesis of fluorinated polymers and specialty chemicals with unique surface properties.
• Cross-Coupling Reactions: Serves as a substrate in palladium-catalyzed reactions (e.g., Suzuki, Sonogashira) for biaryl formation.
• Chemical Biology Probes: Useful for labeling and modifying biomolecules due to its selective reactivity.

Basic Information

Product Name	Perfluorophenyl 4-Iodobenzenesulphonate
CAS No.	885950-39-0
Molecular Formula	C12H4F5IO3S
Molecular Weight	473.12 g/mol
Synonyms	Pentafluorophenyl 4-Iodobenzenesulfonate; 4-Iodobenzenesulfonic Acid Pentafluorophenyl Ester; PFP-Iodobenzenesulfonate; 4-Iodophenylsulfonyl Pentafluorophenyl Ester; Benzenesulfonic Acid, 4-Iodo-, 2,3,4,5,6-Pentafluorophenyl Ester; PFP-OSu (related analogue); Pentafluorophenyl 4-Iodophenylsulfonate
EINECS	Contact for details

Quality Control

Every batch of Perfluorophenyl 4-Iodobenzenesulphonate is manufactured and analyzed under strict quality management systems. We provide comprehensive Certificates of Analysis (COA) that detail purity, identity, and impurity profiles to ensure consistency and reliability for your critical research and production processes. Our quality commitment aligns with cGMP principles for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container sealed under an inert atmosphere such as nitrogen or argon to maximize shelf-life stability. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.