Description

Pentafluorophenyl 5-Bromo-Thiophene-2-Sulfonate is a high-value, multi-functional chemical building block designed for advanced synthetic chemistry. Its core value lies in the unique reactivity of the pentafluorophenyl sulfonate (PFP-sulfonate) group, which serves as an excellent leaving group in nucleophilic substitution reactions, particularly under mild conditions. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and materials science industries who require precise and efficient methods for constructing complex sulfur-containing heterocycles or for introducing functional handles onto molecular scaffolds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel thiophene-based active pharmaceutical ingredients (APIs) and bio-conjugates.
• Agrochemical Research: Used in creating advanced herbicide and fungicide candidates that leverage the thiophene moiety for biological activity.
• Polymer & Materials Science: Serves as a monomer or cross-linking agent in the development of conductive polymers, organic semiconductors, and specialty polymeric materials.
• Ligand & Catalyst Development: Employed to synthesize sophisticated sulfur-containing ligands for transition metal catalysis and organocatalysis.
• Chemical Biology Probes: Useful for labeling biomolecules or creating activity-based probes due to the reactive sulfonate ester group.
• Custom Synthesis & Contract Manufacturing: A critical reagent for custom synthesis houses serving the life sciences sector with tailored, high-purity intermediates.

Basic Information

Item	Detail
Product Name	Pentafluorophenyl 5-Bromo-Thiophene-2-Sulfonate
CAS No.	885949-67-7
Molecular Formula	C10H2BrF5O3S2
Molecular Weight	408.14 g/mol
Synonyms	5-Bromothiophene-2-sulfonic acid pentafluorophenyl ester; 2,3,4,5,6-Pentafluorophenyl 5-bromothiophene-2-sulfonate; PFP-5-Bromo-Thiophene-2-Sulfonate; 5-Bromo-2-thiophenesulfonyl fluoride pentafluorophenyl ester derivative; Pentafluorophenyl 5-bromothiophene-2-sulfonate; 5-Bromothiophene-2-sulfonyl pentafluorophenyl ether
EINECS	Contact for details

Quality Control

Every batch of Pentafluorophenyl 5-Bromo-Thiophene-2-Sulfonate is manufactured and analyzed under strict quality management protocols to ensure consistency and reliability for your critical research and development. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles as determined by advanced analytical techniques. Our commitment to GMP-grade documentation and traceability supports regulatory filings and ensures supply chain integrity for global customers.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is light-sensitive and should be handled under appropriate conditions to maintain stability. Keep container tightly sealed when not in use to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.