Description

Pentafluorophenyl 2-Chloro-Benzenesulfonate is a specialized organosulfur and organofluorine compound that serves as a high-performance sulfonylation reagent and a versatile synthetic intermediate. Its core value lies in its unique reactivity profile, where the pentafluorophenyl group acts as an excellent leaving group, facilitating efficient and selective sulfonate ester formation under mild conditions. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors, particularly for constructing complex molecules, modifying peptides, and developing novel chemical entities.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of active pharmaceutical ingredients (APIs), especially in the development of sulfonamide-based drugs and prodrugs.
• Peptide Modification: Used to selectively sulfonylate amino acid side chains (e.g., tyrosine, lysine) in peptide chemistry and bioconjugation strategies.
• Polymer Chemistry: Acts as a functional monomer or cross-linking agent in the production of specialty polymers with tailored properties.
• Agrochemical Synthesis: Employed in the creation of novel herbicides, fungicides, and insecticides that incorporate sulfonate ester functionalities.
• Material Science: Utilized in surface functionalization and the development of advanced materials, including liquid crystals and organic semiconductors.
• Chemical Biology Probes: Serves as a reagent for labeling biomolecules or creating activity-based probes for enzyme studies.
• Catalyst and Ligand Synthesis: A precursor for synthesizing specialized ligands and organocatalysts used in asymmetric synthesis.
• Research & Development: A valuable tool for academic and industrial R&D in exploring new synthetic methodologies and reaction mechanisms.

Basic Information

Item	Details
Product Name	Pentafluorophenyl 2-Chloro-Benzenesulfonate
CAS No.	885949-55-3
Molecular Formula	C12H4ClF5O3S
Molecular Weight	358.67 g/mol
Synonyms	2-Chlorobenzenesulfonic Acid Pentafluorophenyl Ester; Pentafluorophenyl 2-Chlorobenzenesulfonate; 2-Chlorophenylsulfonyl Pentafluorobenzene; o-Chlorobenzenesulfonyl Pentafluorobenzene; (2-Chlorophenyl)sulfonyl Pentafluorobenzene; Benzenesulfonic Acid, 2-Chloro-, 2,3,4,5,6-Pentafluorophenyl Ester; PFP 2-Chlorobenzenesulfonate
EINECS	Contact for details

Quality Control

Our Pentafluorophenyl 2-Chloro-Benzenesulfonate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing batch-specific results are provided with every shipment. We adhere to cGMP principles where applicable to support our clients in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container sealed to prevent moisture absorption and contamination. Store away from incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.