Description

4-n-Boc-Amino-4-Tetrahydropyrancarboxylic Acid Methyl Ester is a high-purity, protected amino acid derivative that serves as a critical building block in advanced organic synthesis. Its value lies in providing a versatile and reactive scaffold for constructing complex molecules, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries who require reliable, high-quality intermediates for peptide mimetics and active pharmaceutical ingredient (API) synthesis.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel drug candidates, particularly those targeting protease inhibition or requiring constrained peptide backbones.
• Peptidomimetic Chemistry: Used to introduce the tetrahydropyran moiety into peptide chains, enhancing metabolic stability and modifying pharmacokinetic properties.
• Combinatorial Library Synthesis: Serves as a versatile building block for creating diverse chemical libraries for high-throughput screening in drug discovery.
• Agrochemical Research: Employed in the development of new active ingredients with improved efficacy and environmental profiles.
• Academic & Contract Research: Utilized in universities and CROs for methodological development and the synthesis of complex natural product analogs.
• Custom Synthesis Projects: A starting material for the bespoke production of specialized fine chemicals and advanced intermediates.

Basic Information

Product Name	4-n-Boc-Amino-4-Tetrahydropyrancarboxylic Acid Methyl Ester
CAS No.	885498-48-6
Molecular Formula	C13H23NO5
Molecular Weight	273.32 g/mol
Synonyms	Methyl 4-[(tert-butoxycarbonyl)amino]oxane-4-carboxylate; 4-(Boc-amino)tetrahydropyran-4-carboxylic Acid Methyl Ester; Boc-4-Amino-THP-4-Carboxylic Acid Methyl Ester; 4-[(tert-Butoxycarbonyl)amino]tetrahydro-2H-pyran-4-carboxylic Acid Methyl Ester; 4-(tert-Butoxycarbonylamino)tetrahydropyran-4-carboxylic Acid Methyl Ester; 4-N-Boc-Amino-4-THP-Carboxylic Acid Methyl Ester; 4-Boc-Amino-THP-4-COOMe
EINECS	Contact for details

Quality Control

Our production of 4-n-Boc-Amino-4-Tetrahydropyrancarboxylic Acid Methyl Ester adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are available upon request. We support development and commercial projects requiring material that meets internal quality standards or specific pharmacopeial guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.