Description

4-(1H-Indazol-6-Yl)-Tetrahydro-Pyran-4-Ol CAS NO 885272-12-8 is a high-purity, advanced pharmaceutical intermediate featuring a unique molecular scaffold that combines indazole and tetrahydropyran motifs. This compound is of significant value for medicinal chemistry research and development, serving as a critical building block for the synthesis of novel therapeutic agents. It is primarily sought after by pharmaceutical R&D departments and fine chemical manufacturers engaged in developing new drug candidates, particularly in oncology and central nervous system (CNS) disease areas.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel small-molecule drug candidates targeting various disease pathways.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Kinase Inhibitor Development: The indazole core is a privileged structure in the design of potent and selective kinase inhibitors for oncology applications.
• CNS Drug Discovery: Employed in the research of new compounds for neurological and psychiatric disorders due to the favorable physicochemical properties of the scaffold.
• Chemical Biology Probes: Serves as a starting material for creating tool compounds to study specific biological targets and mechanisms.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and GMP production of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	4-(1H-Indazol-6-Yl)-Tetrahydro-Pyran-4-Ol
CAS No.	885272-12-8
Molecular Formula	C12H14N2O2
Molecular Weight	218.25 g/mol
Synonyms	4-(1H-Indazol-6-yl)oxan-4-ol; 4-(1H-Indazol-6-yl)tetrahydro-2H-pyran-4-ol; 4-(6-Indazolyl)-4-hydroxytetrahydropyran; Tetrahydro-2H-pyran-4-ol, 4-(1H-indazol-6-yl)-; 4-(1H-Indazol-6-yl)tetrahydropyran-4-ol; 4-(1H-Indazol-6-Yl)-Tetrahydro-Pyran-4-Ol; 4-(1H-Indazol-6-yl)-4-hydroxytetrahydropyran
EINECS	Contact for details

Quality Control

Our 4-(1H-Indazol-6-Yl)-Tetrahydro-Pyran-4-Ol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be stored away from direct light exposure. Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.