Description

6-Bromo-8-Methoxy-2H-Chromene-3-Carbonitrile is a high-purity, advanced pharmaceutical intermediate characterized by its unique chromene core functionalized with bromo, methoxy, and nitrile groups. This compound is of significant commercial interest for its role as a critical building block in the synthesis of complex organic molecules, particularly in medicinal chemistry. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes due to its versatile reactive sites for further functionalization.
• Organic Synthesis Building Block: Serves as a versatile scaffold for constructing complex heterocyclic compounds and natural product analogs in academic and industrial R&D.
• Agrochemical Research: Potential intermediate in the development of new crop protection agents and herbicides, leveraging its bioactive chromene structure.
• Material Science Precursor: Can be utilized in the synthesis of organic electronic materials or functional dyes, exploring the photophysical properties of the chromene system.

Basic Information

Product Name	6-Bromo-8-Methoxy-2H-Chromene-3-Carbonitrile
CAS No.	885271-24-9
Molecular Formula	C11H8BrNO2
Molecular Weight	266.09 g/mol
Synonyms	6-Bromo-8-methoxy-2H-1-benzopyran-3-carbonitrile; 6-Bromo-8-methoxychromene-3-carbonitrile; 2H-1-Benzopyran-3-carbonitrile, 6-bromo-8-methoxy-; 885271-24-9; 6-Bromo-8-methoxy-2H-chromene-3-carbonitrile; 6-Bromo-8-methoxy-3-cyano-2H-chromene
EINECS	Contact for details

Quality Control

Our 6-Bromo-8-Methoxy-2H-Chromene-3-Carbonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to quality supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents and incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.