Description

8-Bromo-6-Chloro-2H-Chromene-3-Carbonitrile is a high-purity, multi-functional heterocyclic building block of significant interest in advanced organic synthesis. Its unique chromene core, functionalized with bromo, chloro, and nitrile groups, makes it a versatile precursor for constructing complex molecular architectures. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, inflammation, and oncology.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging its halogenated structure for bioactivity.
• Material Science Precursor: Serves as a building block for organic electronic materials, dyes, and photochromic compounds due to the chromene scaffold.
• Chemical Biology Probe: Utilized in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: An essential starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.
• Academic & Institutional Research: Employed in universities and research institutes for methodological studies in heterocyclic and cross-coupling chemistry.

Basic Information

Product Name	8-Bromo-6-Chloro-2H-Chromene-3-Carbonitrile
CAS No.	885271-10-3
Molecular Formula	C10H5BrClNO
Molecular Weight	286.51 g/mol
Synonyms	8-Bromo-6-chloro-2H-1-benzopyran-3-carbonitrile; 6-Chloro-8-bromo-2H-chromene-3-carbonitrile; 3-Cyano-8-bromo-6-chloro-2H-chromene; 8-Bromo-6-chloro-3-cyano-2H-chromene; 2H-1-Benzopyran-3-carbonitrile, 8-bromo-6-chloro-; 885271-10-3
EINECS	Contact for details

Quality Control

Every batch of 8-Bromo-6-Chloro-2H-Chromene-3-Carbonitrile is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and development. A detailed Certificate of Analysis (COA) is available for each lot, confirming identity, purity, and impurity profile.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.