Description

2-(3-Fluoro-4-Hydroxy-Phenyl)-Pyrano[2,3-B]Pyridin-4-One CAS NO 884500-75-8 is a high-purity, fluorinated heterocyclic compound belonging to the pyranopyridine class, serving as a critical advanced pharmaceutical intermediate. Its unique molecular structure, featuring a fused pyrano[2,3-b]pyridin-4-one core substituted with a fluorinated phenol, makes it a valuable building block for medicinal chemistry research and development. This compound is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology sectors for the synthesis of novel active pharmaceutical ingredients (APIs) and drug candidates.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of new drug molecules, particularly in oncology, neurology, and anti-inflammatory therapeutic areas.
• Medicinal Chemistry Research: Used as a scaffold or building block for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• API Synthesis: Employed in the multi-step synthesis of complex Active Pharmaceutical Ingredients (APIs) that require fluorinated heterocyclic components.
• Biochemical Tool Compound: Serves as a research chemical for probing biological pathways and enzyme interactions in academic and industrial laboratories.
• Process Chemistry Development: Used in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales.
• Custom Synthesis: A starting material for the contract manufacturing of specialized fluorinated compounds for client-specific applications.

Basic Information

Product Name	2-(3-Fluoro-4-Hydroxy-Phenyl)-Pyrano[2,3-B]Pyridin-4-One
CAS No.	884500-75-8
Molecular Formula	C₁₄H₈FNO₃
Molecular Weight	257.22 g/mol
Synonyms	2-(3-Fluoro-4-hydroxyphenyl)-4H-pyrano[2,3-b]pyridin-4-one; 4H-Pyrano[2,3-b]pyridin-4-one, 2-(3-fluoro-4-hydroxyphenyl)-; 2-(3-Fluoro-4-Hydroxy-Phenyl)-4H-Pyrano[2,3-b]Pyridin-4-One; 884500-75-8; Fluorinated Pyranopyridinone; 3-Fluoro-4-hydroxy phenyl pyranopyridinone derivative
EINECS	Contact for details

Quality Control

Our 2-(3-Fluoro-4-Hydroxy-Phenyl)-Pyrano[2,3-B]Pyridin-4-One is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing specifications such as assay (by HPLC), related substances, and residual solvents. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.