Description

1H-Pyrrolo[2,3-B]Pyridine, 4-Chloro-5-Fluoro-1-[(4-Methylphenyl)Sulfonyl]-2-(Tributylstannyl)- is a high-purity organotin intermediate of significant importance in modern pharmaceutical and agrochemical research. This compound is specifically engineered for use in Stille cross-coupling reactions, enabling the efficient construction of complex heterocyclic scaffolds. It is an essential building block for medicinal chemists and R&D teams developing novel active pharmaceutical ingredients (APIs) and crop protection agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly those targeting kinase inhibition and other therapeutic areas.
• Stille Coupling Reagent: Enables the formation of carbon-carbon bonds under mild conditions, crucial for constructing advanced molecular architectures in medicinal chemistry.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides with novel modes of action.
• Material Science: Potential applications in the synthesis of organic electronic materials and functional polymers.
• Academic & Contract Research: Serves as a specialized reagent for method development and discovery chemistry in university and CRO laboratories.
• Process Chemistry Development: Supports scale-up and optimization of synthetic routes for pilot and commercial-scale production.

Basic Information

Product Name	1H-Pyrrolo[2,3-B]Pyridine, 4-Chloro-5-Fluoro-1-[(4-Methylphenyl)Sulfonyl]-2-(Tributylstannyl)-
CAS No.	882033-68-3
Molecular Formula	C26H36ClFN2O2SSn
Molecular Weight	622.76 g/mol
Synonyms	4-Chloro-5-fluoro-1-[(4-methylphenyl)sulfonyl]-2-(tributylstannyl)-1H-pyrrolo[2,3-b]pyridine; 1-Tosyl-4-chloro-5-fluoro-2-(tributylstannyl)-7-azaindole; 4-Chloro-5-fluoro-1-(p-tolylsulfonyl)-2-(tributylstannyl)-1H-pyrrolo[2,3-b]pyridine; 2-(Tributylstannyl)-4-chloro-5-fluoro-1-tosyl-1H-pyrrolo[2,3-b]pyridine; 7-Azaindole Stille Reagent; Organotin Building Block 882033-68-3
EINECS	Contact for details

Quality Control

Our 1H-Pyrrolo[2,3-B]Pyridine, 4-Chloro-5-Fluoro-1-[(4-Methylphenyl)Sulfonyl]-2-(Tributylstannyl)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR (¹H, ¹³C, ¹⁹F), HPLC, and elemental analysis, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our production adheres to cGMP guidelines where applicable, ensuring reliability for your most demanding research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C in a freezer. This compound is easily oxidized and moisture-sensitive; prolonged exposure to air or ambient conditions should be avoided. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Tin Content	18.5 - 19.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.