Description

Sodium (n-(Boc)-2-Indolyl)Dimethylsilanolate is a specialized organosilicon reagent featuring a protected indole moiety. This compound is valued for its role as a key synthetic intermediate in advanced organic and medicinal chemistry, enabling precise molecular construction. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs) and complex heterocyclic compounds.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of complex drug candidates, particularly those containing indole or tryptophan-derived structures.
• Peptide Mimetics Research: Used in the development of peptidomimetics and constrained peptides where the silanolate group facilitates unique coupling or protection strategies.
• Organometallic Catalysis: Serves as a ligand precursor or modifying agent in transition metal-catalyzed cross-coupling reactions.
• Material Science: Potential application in the synthesis of functionalized silicon-based polymers or hybrid organic-inorganic materials.
• Agrochemical Synthesis: Intermediate for creating novel compounds with potential biological activity for crop protection.

Basic Information

Product Name	Sodium (n-(Boc)-2-Indolyl)Dimethylsilanolate
CAS No.	879904-86-6
Molecular Formula	C15H20NNaO3Si
Molecular Weight	313.41 g/mol
Synonyms	Sodium (N-Boc-2-indolyl)dimethylsilanolate; Sodium (1-(tert-Butoxycarbonyl)-1H-indol-2-yl)dimethylsilanolate; (N-Boc-2-Indolyl)dimethylsilanol Sodium Salt; Dimethyl[(1-{[(1,1-dimethylethyl)oxy]carbonyl}-1H-indol-2-yl)oxy]silanolate Sodium; tert-Butyl 2-(dimethyl(sodiooxy)silyl)-1H-indole-1-carboxylate
EINECS	Contact for details

Quality Control

Our Sodium (n-(Boc)-2-Indolyl)Dimethylsilanolate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable to support our clients in regulated development pathways.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept sealed under an inert atmosphere (argon or nitrogen) when not in use to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.