Description

4(R)-Amino-6-Fluoro-2(R)-Methylchroman-4-Carboxylic Acid is a high-purity chiral building block of significant interest in advanced pharmaceutical synthesis. This compound matters because it provides a structurally defined, enantiomerically pure scaffold essential for developing novel active pharmaceutical ingredients (APIs) with targeted therapeutic effects. Pharmaceutical R&D teams and fine chemical manufacturers need this intermediate for the production of complex drug candidates, particularly in therapeutic areas requiring high stereochemical control.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new chemical entities (NCEs), especially for central nervous system (CNS) and cardiovascular drugs.
• Active Pharmaceutical Ingredient (API) Synthesis: Serves as a critical precursor in multi-step synthetic routes for constructing complex, fluorinated chroman-based APIs.
• Asymmetric Synthesis: Utilized in stereoselective reactions to introduce the chiral 4-amino and 2-methyl substituents onto the chroman core.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to explore the impact of the fluorine atom and stereochemistry on biological activity.
• Process Chemistry & Scale-Up: Used in the development and optimization of commercial-scale manufacturing processes for target molecules.
• Contract Manufacturing (CMO): Supplied to contract research and manufacturing organizations (CRAMOs) for custom synthesis projects.

Basic Information

Product Name	4(R)-Amino-6-Fluoro-2(R)-Methylchroman-4-Carboxylic Acid
CAS No.	875312-64-4
Molecular Formula	C12H14FNO3
Molecular Weight	239.24 g/mol
Synonyms	(4R)-Amino-6-fluoro-2-methyl-3,4-dihydro-2H-1-benzopyran-4-carboxylic acid; 6-Fluoro-2-methylchroman-4-carboxylic acid, 4-amino-, (2R,4R)-; (2R,4R)-4-Amino-6-fluoro-2-methylchroman-4-carboxylic acid; 4-Amino-6-fluoro-2-methyl-3,4-dihydro-2H-chromene-4-carboxylic acid; (4R)-4-Amino-6-fluoro-2-methyl-3,4-dihydro-2H-chromene-4-carboxylic acid; 4(R)-Amino-6-Fluoro-2(R)-Methylchroman-4-Carboxylic Acid; 4-Amino-6-fluoro-2-methylchroman-4-carboxylic acid (enantiomer); 875312-64-4
EINECS	Contact for details

Quality Control

Our 4(R)-Amino-6-Fluoro-2(R)-Methylchroman-4-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity and standard pharmacopeial methods for identity and impurity profiling, to ensure it meets the exacting standards required for pharmaceutical development. Certificates of Analysis (COA) detailing purity, chiral excess, and related substances are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.