Description

5-Bromo-1-Methylene-2,3-Dihydro-1H-Indene is a versatile brominated indene derivative that serves as a critical synthetic intermediate in advanced organic chemistry. Its unique fused-ring structure with a reactive exocyclic methylene group makes it a valuable building block for constructing complex molecular architectures. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and inflammatory pathways.
• Agrochemical Research: Building block for developing new herbicides, fungicides, and insecticides with enhanced efficacy and selectivity.
• Material Science: Monomer or precursor for creating specialized polymers, liquid crystals, and organic electronic materials.
• Organic Synthesis: Versatile reagent for Diels-Alder reactions, cross-coupling reactions (e.g., Suzuki, Heck), and other carbon-carbon bond-forming transformations.
• Chemical Biology: Useful scaffold for designing molecular probes and enzyme inhibitors in biochemical research.
• Catalyst Ligand Development: Potential precursor for synthesizing novel ligands used in asymmetric catalysis.

Basic Information

Product Name	5-Bromo-1-Methylene-2,3-Dihydro-1H-Indene
CAS No.	875306-81-3
Molecular Formula	C10H9Br
Molecular Weight	209.08 g/mol
Synonyms	5-Bromo-1-methyleneindane; 1H-Indene, 5-bromo-1-methylene-2,3-dihydro-; 5-Bromo-1-methyleneindan; 2,3-Dihydro-5-bromo-1-methylene-1H-indene; 5-Bromoindene, 1-methylene-2,3-dihydro derivative
EINECS	Contact for details

Quality Control

Our 5-Bromo-1-Methylene-2,3-Dihydro-1H-Indene is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is subjected to comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to verify identity and purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes. We adhere to cGMP principles where applicable to support our customers in regulated research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon to maximize stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.