Description

Methyl 6-Fluoro-3,4-Dihydro-2H-Chromene-2-Carboxylate is a high-purity fluorinated chromane derivative, serving as a critical advanced intermediate in modern organic synthesis. Its value lies in providing a versatile, functionalized scaffold for constructing complex molecules, particularly in pharmaceutical research and development. This compound is essential for chemists and R&D teams in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop new active ingredients.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, cardiovascular diseases, and anti-inflammatory applications.
• Agrochemical Research: Used in the development of new-generation pesticides and herbicides, where the fluorinated chromane structure can enhance biological activity and environmental stability.
• Material Science Precursor: Serves as a monomer or functional additive in the synthesis of specialized polymers and advanced organic materials with tailored optical or electronic properties.
• Chemical Biology Probe: Utilized as a core structure for creating fluorescent tags or molecular probes to study biological processes and enzyme interactions.
• Academic & Contract Research: An important reagent for methodology development and exploratory chemistry in university laboratories and contract research organizations (CROs).

Basic Information

Product Name	Methyl 6-Fluoro-3,4-Dihydro-2H-Chromene-2-Carboxylate
CAS No.	874649-82-8
Molecular Formula	C11H11FO3
Molecular Weight	210.20 g/mol
Synonyms	6-Fluoro-3,4-dihydro-2H-chromene-2-carboxylic acid methyl ester; Methyl 6-fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxylate; 2H-1-Benzopyran-2-carboxylic acid, 6-fluoro-3,4-dihydro-, methyl ester; 6-Fluorochroman-2-carboxylic acid methyl ester; Methyl 6-fluorochromane-2-carboxylate
EINECS	Contact for details

Quality Control

Our production of Methyl 6-Fluoro-3,4-Dihydro-2H-Chromene-2-Carboxylate adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. All materials are subjected to rigorous analytical testing, including HPLC, GC, NMR, and MS, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed when not in use to prevent contamination and moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.