Description

(2R,3R,4R,5S,6S)-2-(Acetoxymethyl)-6-(4-Chloro-3-(4-Methoxybenzyl)Phenyl)Tetrahydro-2H-Pyran-3,4,5-Triyl Triacetate is a high-purity, stereochemically defined advanced pharmaceutical intermediate. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs) where precise molecular architecture is required for biological activity. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development and production of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of complex, target-specific active pharmaceutical ingredients (APIs).
• Research & Development: Used in medicinal chemistry for the discovery and optimization of new drug candidates, particularly in metabolic and central nervous system (CNS) disease research.
• Process Chemistry: Serves as a critical chiral intermediate in scale-up and process development for commercial drug manufacturing.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high stereochemical purity.
• Academic Research: Utilized in university and institutional labs for studying glycosidase inhibition or related biochemical pathways.

Basic Information

Product Name	(2R,3R,4R,5S,6S)-2-(Acetoxymethyl)-6-(4-Chloro-3-(4-Methoxybenzyl)Phenyl)Tetrahydro-2H-Pyran-3,4,5-Triyl Triacetate
CAS No.	872980-38-6
Molecular Formula	C30H33ClO10
Molecular Weight	589.03 g/mol
Synonyms	Canagliflozin Impurity 1; Canagliflozin Related Compound A; (2R,3R,4R,5S,6S)-2-(Acetoxymethyl)-6-[4-chloro-3-[(4-methoxyphenyl)methyl]phenyl]tetrahydro-2H-pyran-3,4,5-triyl triacetate; 1-(4-Chloro-3-(4-methoxybenzyl)phenyl)-1-deoxy-β-D-glucopyranose 2,3,4,6-tetraacetate; SGLT2 Inhibitor Intermediate; 872980-38-6; INV-872980-38-6
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and high chemical purity. Quality is verified through comprehensive analytical methods including HPLC, GC, and NMR. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 99.0%
Single Maximum Impurity	≤ 0.5%
Total Impurities	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.