Description

1-[(S)-2-Hydroxy-1-(Phenylmethyl)Ethyl]-3-(2,4,6-Trimethylphenyl)-4,5-Dihydro-1H-Imidazolium Hexafluorophosphate is a high-purity, chiral imidazolium salt primarily utilized as a specialized catalyst or chiral auxiliary in advanced organic synthesis. This compound matters for its role in facilitating stereoselective transformations, enabling the production of enantiomerically enriched intermediates critical for pharmaceutical and fine chemical development. It is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries who require precise control over molecular chirality.

Application

• Asymmetric Catalysis: Employed as a chiral catalyst or catalyst precursor in enantioselective synthesis, including hydrogenation and carbon-carbon bond-forming reactions.
• Pharmaceutical Intermediate Synthesis: Used in the research and development of active pharmaceutical ingredients (APIs) where specific stereochemistry is required for biological activity.
• Ligand Synthesis: Serves as a precursor for the preparation of chiral N-heterocyclic carbene (NHC) ligands for transition metal catalysis.
• Fine Chemical Production: Applied in the manufacture of complex, high-value specialty chemicals and fragrances requiring chiral purity.
• Academic & Industrial Research: A valuable reagent for methodological development in organic chemistry and process chemistry laboratories.

Basic Information

Product Name	1-[(S)-2-Hydroxy-1-(Phenylmethyl)Ethyl]-3-(2,4,6-Trimethylphenyl)-4,5-Dihydro-1H-Imidazolium Hexafluorophosphate
CAS No.	872164-49-3
Molecular Formula	C21H27N2O•PF6
Molecular Weight	444.42 g/mol
Synonyms	(S)-1-(2-Hydroxy-1-phenylethyl)-3-(2,4,6-trimethylphenyl)-4,5-dihydro-1H-imidazol-3-ium hexafluorophosphate; Chiral Imidazolium Hexafluorophosphate Salt; NHC Precursor Salt; (S)-1-(2-Hydroxy-1-phenylethyl)-3-mesitylimidazolium Hexafluorophosphate; (S)-1-(2-Hydroxy-1-phenylethyl)-3-mesityl-4,5-dihydro-1H-imidazol-3-ium Hexafluorophosphate; 1-[(1S)-2-Hydroxy-1-phenylethyl]-3-(2,4,6-trimethylphenyl)-4,5-dihydro-1H-imidazol-3-ium Hexafluorophosphate
EINECS	Contact for details

Quality Control

Our 1-[(S)-2-Hydroxy-1-(Phenylmethyl)Ethyl]-3-(2,4,6-Trimethylphenyl)-4,5-Dihydro-1H-Imidazolium Hexafluorophosphate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for synthetic applications. Certificates of Analysis (COA) with detailed specifications are provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.