Description

n-[3,5-Bis(Trifluoromethyl)Phenyl]-N'-[(1R,2S)-2,3-Dihydro-2-Hydroxy-1H-Inden-1-Yl]-Thiourea is a high-purity, chiral thiourea derivative of significant interest in advanced organic synthesis. This compound is valued for its role as a sophisticated organocatalyst and a key pharmaceutical intermediate in the development of enantiomerically pure active ingredients. It is primarily utilized by research institutions and pharmaceutical companies engaged in asymmetric synthesis, medicinal chemistry, and process development for novel therapeutics.

Application

• Asymmetric Organocatalysis: Employed as a chiral hydrogen-bond donor catalyst for enantioselective reactions, including Michael additions and aldol condensations.
• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of enantiomerically pure drug candidates, particularly in central nervous system (CNS) and antiviral research.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its unique trifluoromethyl-phenyl and indanol motifs.
• Chiral Ligand Precursor: Can be utilized in the development of chiral ligands for transition metal catalysis.
• Process Chemistry Development: Integral to scaling up synthetic routes for target molecules requiring high enantiomeric excess (ee).
• Academic & Industrial R&D: A valuable reagent for methodological development in organic synthesis at universities and corporate R&D centers.

Basic Information

Product Name	n-[3,5-Bis(Trifluoromethyl)Phenyl]-N'-[(1R,2S)-2,3-Dihydro-2-Hydroxy-1H-Inden-1-Yl]-Thiourea
CAS No.	871828-95-4
Molecular Formula	C19H14F6N2OS
Molecular Weight	432.39 g/mol
Synonyms	(1R,2S)-N-[3,5-Bis(trifluoromethyl)phenyl]-N'-(2-hydroxy-2,3-dihydro-1H-inden-1-yl)thiourea; (1R,2S)-1-({[3,5-Bis(trifluoromethyl)phenyl]carbamothioyl}amino)-2,3-dihydro-1H-inden-2-ol; Chiral Thiourea Catalyst; BTFI Thiourea Derivative; Indanol-Based Thiourea; Organocatalyst 871828-95-4; Enantiopure Thiourea; Asymmetric Synthesis Reagent
EINECS	Contact for details

Quality Control

Our production of n-[3,5-Bis(Trifluoromethyl)Phenyl]-N'-[(1R,2S)-2,3-Dihydro-2-Hydroxy-1H-Inden-1-Yl]-Thiourea adheres to stringent quality protocols to ensure batch-to-batch consistency and high enantiomeric purity. All material is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral purity, and impurity profiles. We operate under a cGMP-compliant quality management system, ensuring traceability and documentation suitable for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.