Description

1,4,7,10-Tetraazacyclododecane-1,7-Diacetic Acid, Bis(Phenylmethyl) Ester is a key protected intermediate in the synthesis of sophisticated macrocyclic chelating agents. This compound is essential for researchers and manufacturers developing advanced contrast agents for medical imaging and targeted radiopharmaceuticals. It is primarily utilized in pharmaceutical R&D and fine chemical synthesis, where high-purity building blocks are critical for product efficacy and regulatory compliance.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) and its derivatives, which are foundational chelators for gadolinium and other lanthanides.
• Contrast Agent Development: Used in research and production of next-generation MRI contrast agents, enabling improved image clarity and diagnostic accuracy.
• Radiopharmaceuticals: Serves as a building block for bifunctional chelators that bind radioactive isotopes (e.g., 68Ga, 177Lu, 90Y) to targeting vectors for cancer diagnosis and therapy.
• Chemical Research: Employed in academic and industrial laboratories for studying macrocyclic chemistry, coordination complexes, and metal ion sequestration.
• Fine Chemical Synthesis: Acts as a specialized intermediate for creating custom-designed ligands with specific binding properties for catalysis or sensing applications.

Basic Information

Product Name	1,4,7,10-Tetraazacyclododecane-1,7-Diacetic Acid, Bis(Phenylmethyl) Ester
CAS No.	871544-37-5
Molecular Formula	C30H42N4O4
Molecular Weight	522.68 g/mol
Synonyms	DOTA-Bn2; 1,7-Bis(benzyloxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane; 1,7-Bis(benzyl acetate)-DOTA; 1,4,7,10-Tetraazacyclododecane-1,7-diacetic acid dibenzyl ester; DOTA-1,7-diacetic acid bis(phenylmethyl) ester; Protected DOTA intermediate; Cyclen-1,7-diacetic acid dibenzyl ester
EINECS	Contact for details

Quality Control

Our production of this high-value intermediate adheres to stringent quality protocols to ensure batch-to-batch consistency and purity essential for sensitive pharmaceutical applications. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive; prolonged exposure should be avoided to maintain stability. Keep the container sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.