Description

Methanesulfonic Acid, 1,1,1-Trifluoro-, 2-Chloro-3-(4-Propyl-1-Piperazinyl)Phenyl Ester is a specialized fluorinated methanesulfonate ester derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring a trifluoromethanesulfonyl (triflyl) group and a substituted piperazine moiety, makes it a valuable reagent for introducing specific functional groups and modulating the physicochemical properties of target molecules. This high-purity intermediate is primarily utilized by pharmaceutical and agrochemical research organizations for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of potential drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Agrochemical Research: Used in the development of new-generation herbicides, fungicides, and insecticides, where the fluorine and sulfonate groups can enhance bioavailability and environmental stability.
• Material Science: Serves as a monomer or cross-linking agent in the synthesis of specialty polymers with tailored surface properties, thermal stability, or chemical resistance.
• Chemical Biology Probe Synthesis: Employed to create labeled compounds or activity-based probes for studying enzyme function and biological pathways.
• Ligand and Catalyst Development: Useful precursor for constructing complex ligands used in asymmetric catalysis and transition metal complexes.

Basic Information

Product Name	Methanesulfonic Acid, 1,1,1-Trifluoro-, 2-Chloro-3-(4-Propyl-1-Piperazinyl)Phenyl Ester
CAS No.	871356-22-8
Molecular Formula	C14H17ClF3N2O3S
Molecular Weight	385.81 g/mol
Synonyms	2-Chloro-3-(4-propylpiperazin-1-yl)phenyl trifluoromethanesulfonate; 1-(2-Chloro-3-(trifluoromethanesulfonyloxy)phenyl)-4-propylpiperazine; Trifluoromethanesulfonic Acid 2-Chloro-3-(4-propyl-1-piperazinyl)phenyl Ester; 871356-22-8; 2-Chloro-3-(4-propylpiperazin-1-yl)phenyl Triflate
EINECS	Contact for details

Quality Control

Every batch of Methanesulfonic Acid, 1,1,1-Trifluoro-, 2-Chloro-3-(4-Propyl-1-Piperazinyl)Phenyl Ester (CAS 871356-22-8) is manufactured under strict quality management systems and undergoes comprehensive analytical characterization to ensure identity, purity, and consistency. Our products are supported by a detailed Certificate of Analysis (COA) that includes data from NMR (1H, 13C), HPLC, and mass spectrometry. We adhere to cGMP guidelines where applicable for pharmaceutical intermediates, ensuring traceability and documentation for regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation from atmospheric moisture. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.