Description

(R)-Amino-(Tetrahydro-Pyran-4-Yl)-Acetic Acid Methyl Ester is a high-value, non-natural amino acid derivative that serves as a critical chiral building block in advanced organic synthesis. Its defined stereochemistry and functionalized pyranyl ring make it indispensable for constructing complex molecular architectures with high enantiomeric purity. This compound is primarily sought after by pharmaceutical R&D and fine chemical manufacturers for applications in drug discovery, process chemistry, and the development of novel active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel therapeutic agents, particularly for central nervous system (CNS) and metabolic disease targets.
• Peptidomimetics & Bioactive Molecule Design: Used to incorporate constrained, ring-structured amino acid analogs into peptides to enhance metabolic stability and receptor selectivity.
• Asymmetric Catalysis & Ligand Synthesis: Serves as a precursor for chiral ligands and organocatalysts used in enantioselective transformations.
• Agrochemical Research: Employed in the development of advanced, stereochemically-defined pesticides and herbicides.
• Academic & Contract Research: A valuable reagent for methodological studies in synthetic organic chemistry and medicinal chemistry programs.
• Custom Synthesis & Scale-Up: A starting material for the contract manufacturing of proprietary compounds under cGMP or ISO standards.

Basic Information

Product Name	(R)-Amino-(Tetrahydro-Pyran-4-Yl)-Acetic Acid Methyl Ester
CAS No.	871301-35-8
Molecular Formula	C9H17NO3
Molecular Weight	187.24 g/mol
Synonyms	Methyl (R)-2-amino-2-(tetrahydro-2H-pyran-4-yl)acetate; (R)-2-Amino-2-(tetrahydropyran-4-yl)acetic acid methyl ester; (R)-Amino(tetrahydro-2H-pyran-4-yl)acetic acid methyl ester; (R)-ATPA Methyl Ester; (R)-2-(Tetrahydro-2H-pyran-4-yl)glycine methyl ester; (R)-TPG-OMe; (R)-Methyl 2-amino-2-(oxan-4-yl)acetate; (R)-4-Pyranylglycine methyl ester
EINECS	Contact for details

Quality Control

Our production of (R)-Amino-(Tetrahydro-Pyran-4-Yl)-Acetic Acid Methyl Ester adheres to stringent quality protocols suitable for pharmaceutical R&D and fine chemical applications. Each batch is characterized by advanced analytical techniques to ensure identity, purity, and enantiomeric excess. Certificates of Analysis (COA) are provided, detailing specifications for assay, chiral purity (typically >99% ee), and related substances. We support development with custom purity grades and analytical method development upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions or an inert atmosphere to prevent degradation. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Enantiomeric Excess (Chiral HPLC)	≥99.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.