Description

(S)-2-(Methylamino)-2-Oxo-1-Phenylethyl 4-Methylbenzenesulfonate is a high-purity chiral building block and pharmaceutical intermediate of significant commercial interest. This compound is valued for its role in the synthesis of complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and fine chemicals. It is primarily sought after by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in advanced synthetic chemistry and process development.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and production of novel therapeutic agents, including potential central nervous system (CNS) drugs.
• Asymmetric Synthesis: Used as a precursor or reagent in stereoselective chemical reactions to construct molecules with defined three-dimensional configurations.
• Process Chemistry Development: Serves as a critical material for route scouting, optimization, and scale-up studies in API manufacturing.
• Academic & Industrial Research: Employed in medicinal chemistry programs for lead compound generation and structure-activity relationship (SAR) studies.
• Fine Chemical Production: Utilized in the custom synthesis of specialty chemicals requiring high enantiomeric purity.

Basic Information

Product Name	(S)-2-(Methylamino)-2-Oxo-1-Phenylethyl 4-Methylbenzenesulfonate
CAS No.	871224-68-9
Molecular Formula	C₁₆H₁₇NO₄S
Molecular Weight	319.38 g/mol
Synonyms	(S)-2-(Methylamino)-2-oxo-1-phenylethyl 4-methylbenzenesulfonate; (S)-N-Methyl-2-oxo-2-(phenylacetamido)ethyl p-toluenesulfonate; L-Phenylglycinol, N-methyl-, p-toluenesulfonate derivative; (S)-O-Tosyl Mandelic Acid Methylamide; (S)-α-(Methylcarbamoyl)benzyl Tosylate; (S)-Mandelic acid methylamide tosylate; (S)-2-(N-Methylamino)-2-oxo-1-phenylethyl tosylate
EINECS	Contact for details

Quality Control

Our (S)-2-(Methylamino)-2-Oxo-1-Phenylethyl 4-Methylbenzenesulfonate is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including chiral purity (enantiomeric excess) verification, to ensure it meets the exacting standards required for pharmaceutical R&D and production. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is moisture-sensitive; keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.