Description

N,n-Di-Boc-2-Iodoaniline is a high-purity, protected aniline derivative widely used as a critical synthetic intermediate in advanced organic chemistry. Its value lies in the dual Boc (tert-butoxycarbonyl) protecting groups, which provide orthogonal deprotection strategies, and the iodine atom, which enables versatile cross-coupling reactions. This compound is essential for researchers and manufacturers in pharmaceutical development, particularly in the synthesis of complex active pharmaceutical ingredients (APIs) and for creating specialized agrochemicals and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially in medicinal chemistry for constructing complex aromatic and heterocyclic scaffolds.
• Cross-Coupling Reactions: Serves as a versatile electrophile in palladium-catalyzed reactions such as Suzuki-Miyaura, Stille, and Buchwald-Hartwig amination for C-C and C-N bond formation.
• Agrochemical Synthesis: Used in the research and development of advanced herbicides, fungicides, and plant growth regulators.
• Material Science Research: Intermediate for the preparation of organic semiconductors, liquid crystals, and other functional organic materials.
• Chemical Biology & Proteomics: Useful in the synthesis of probes, tags, and linkers for studying biological systems.
• Academic & R&D Laboratories: A valuable reagent for methodological development and complex molecule synthesis in university and industrial research settings.

Basic Information

Product Name	N,n-Di-Boc-2-Iodoaniline
CAS No.	870703-53-0
Molecular Formula	C₁₆H₂₂INO₄
Molecular Weight	419.26 g/mol
Synonyms	2-Iodo-N,N-bis(tert-butoxycarbonyl)aniline; Di-tert-butyl (((2-iodophenyl)imino)bis(methylene))dicarbamate; N,N-Bis-Boc-2-iodoaniline; 1,1'-(2-Iodophenylazanediyl)bis(2-methylpropan-2-yl) dicarbamate; N,N-Di-Boc-2-iodobenzenamine; N,N-Di-tert-butoxycarbonyl-2-iodoaniline; 2-Iodo-N,N-di-Boc-aniline; N,N-Bis(tert-butoxycarbonyl)-2-iodoaniline
EINECS	Contact for details

Quality Control

Our N,n-Di-Boc-2-Iodoaniline is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as identity, purity, and impurity profiles. We adhere to industry best practices and can provide material suitable for research and development under cGMP guidelines upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.