Description

2-Amino-1,9-Dihydro-9-[(1S,3R,4S)-4-(Hydroxydimethylsilyl)-3-(Hydroxymethyl)-2-Methylenecyclopentyl]-6H-Purin-6-One is a sophisticated nucleoside analog intermediate of significant interest in advanced pharmaceutical research and development. Its complex structure, featuring a modified purine base and a unique silyl-protected cyclopentyl moiety, makes it a critical building block for the synthesis of novel antiviral and anticancer therapeutics. This high-purity compound is essential for research institutions, CROs/CDMOs, and pharmaceutical companies engaged in the discovery and process development of next-generation nucleotide-based drugs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel nucleoside analog prodrugs, particularly for antiviral and anticancer applications.
• Antiviral Drug Research: Serves as a core scaffold for developing therapeutics targeting viruses such as hepatitis B (HBV), hepatitis C (HCV), and other viral pathogens.
• Oncology Research: Used in the design and synthesis of experimental chemotherapeutic agents that target DNA/RNA synthesis in cancer cells.
• Process Chemistry & Scale-Up: Employed by contract development and manufacturing organizations (CDMOs) for process optimization and cGMP manufacturing of active pharmaceutical ingredients (APIs).
• Biochemical Research: Acts as a substrate or inhibitor in enzymatic studies to understand nucleotide metabolism and related biological pathways.
• ProTide Technology Intermediate: A potential intermediate for the synthesis of ProTide prodrugs, a technology platform used to enhance the delivery and efficacy of nucleotide analogs.

Basic Information

Product Name	2-Amino-1,9-Dihydro-9-[(1S,3R,4S)-4-(Hydroxydimethylsilyl)-3-(Hydroxymethyl)-2-Methylenecyclopentyl]-6H-Purin-6-One
CAS No.	870614-82-7
Molecular Formula	C15H23N5O3Si
Molecular Weight	349.47 g/mol
Synonyms	9-[(1S,3R,4S)-4-[(Dimethylhydroxysilyl)-3-(hydroxymethyl)-2-methylenecyclopentyl]guanine; 2-Amino-9-[(1S,3R,4S)-4-(hydroxydimethylsilyl)-3-(hydroxymethyl)-2-methylenecyclopentyl]-1,9-dihydro-6H-purin-6-one; Cyclopentyl Guanosine Silyl Ether Intermediate; Nucleoside Silyl Ether Intermediate; Antiviral Nucleoside Intermediate; CAS 870614-82-7
EINECS	Contact for details

Quality Control

Our 2-Amino-1,9-Dihydro-9-[(1S,3R,4S)-4-(Hydroxydimethylsilyl)-3-(Hydroxymethyl)-2-Methylenecyclopentyl]-6H-Purin-6-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis, and comprehensive identification, to ensure it meets the exacting standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability, consistency, and compliance with your research or development protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.