Description

tert-Butyl 3-acetylazetidine-1-carboxylate is a high-purity, protected azetidine derivative serving as a critical chiral building block in advanced organic synthesis. Its value lies in providing a versatile, nitrogen-containing heterocyclic scaffold that is essential for constructing complex molecular architectures with precise stereochemistry. This compound is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients, particularly in medicinal chemistry programs targeting novel therapeutics.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, particularly for central nervous system (CNS) and anti-infective agents.
• Medicinal Chemistry Building Block: Used in parallel and combinatorial synthesis for creating focused libraries to explore structure-activity relationships (SAR).
• Agrochemical Synthesis: Serves as a precursor in the development of novel herbicides, fungicides, and insecticides with improved efficacy.
• Ligand and Catalyst Development: Employed in the synthesis of novel chiral ligands and organocatalysts for asymmetric synthesis.
• Peptidomimetic Research: The azetidine ring acts as a constrained surrogate for amino acids in the design of peptide analogs with enhanced metabolic stability.
• Academic and R&D Laboratories: Used in fundamental research exploring new synthetic methodologies and heterocyclic chemistry.

Basic Information

Product Name	tert-Butyl 3-Acetylazetidine-1-Carboxylate
CAS No.	870089-49-9
Molecular Formula	C10H17NO3
Molecular Weight	199.25 g/mol
Synonyms	1-Boc-3-acetylazetidine; 3-Acetyl-1-azetidinecarboxylic acid 1,1-dimethylethyl ester; tert-Butyl 3-acetyl-1-azetidinecarboxylate; 1-(tert-Butoxycarbonyl)-3-acetylazetidine; 3-Acetylazetidine-1-carboxylic acid tert-butyl ester; Azetidine-1-carboxylic acid, 3-acetyl-, 1,1-dimethylethyl ester; Boc-3-acetylazetidine
EINECS	Contact for details

Quality Control

Our tert-Butyl 3-acetylazetidine-1-carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and consistent performance. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The product is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if necessary for long-term storage.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.