Description

1-(Bromomethyl)-3-(Trifluoromethylsulfonyl)Benzene is a high-value, multi-functional aromatic building block featuring both a reactive bromomethyl group and a robust trifluoromethylsulfonyl (triflyl) moiety. This unique combination makes it a critical intermediate for the synthesis of advanced materials and active pharmaceutical ingredients (APIs), where it introduces both lipophilicity and metabolic stability. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in kinase inhibitor and antiviral research, leveraging the triflyl group for enhanced binding affinity and pharmacokinetic properties.
• Agrochemical Synthesis: Used in creating advanced herbicides and fungicides where the trifluoromethylsulfonyl group contributes to weatherfastness and biological activity.
• Ligand & Catalyst Development: Serves as a precursor for sophisticated ligands in transition metal catalysis, enabling challenging cross-coupling and functionalization reactions.
• Material Science Monomer: Incorporated into polymers and advanced organic frameworks to impart specific electronic, thermal, or surface properties.
• Chemical Biology Probes: Utilized in the design of activity-based probes and molecular tags for studying biological systems due to its reactive handle and distinct spectroscopic signature.
• Fluorinated Compound Library Synthesis: A versatile reagent for medicinal chemistry campaigns aimed at exploring fluorine-containing chemical space for lead optimization.

Basic Information

Product Name	1-(Bromomethyl)-3-(Trifluoromethylsulfonyl)Benzene
CAS No.	866208-07-3
Molecular Formula	C8H6BrF3O2S
Molecular Weight	303.10 g/mol
Synonyms	3-(Bromomethyl)phenyl Trifluoromethanesulfonate; α-Bromo-3-(trifluoromethylsulfonyl)toluene; m-(Trifluoromethylsulfonyl)benzyl Bromide; 3-(Triflyl)benzyl Bromide; 1-Bromomethyl-3-triflylbenzene; [3-(Trifluoromethanesulfonyl)phenyl]methyl Bromide; (3-(Trifluoromethylsulfonyl)phenyl)methyl Bromide
EINECS	Contact for details

Quality Control

Our production of 1-(Bromomethyl)-3-(Trifluoromethylsulfonyl)Benzene adheres to stringent in-process controls and final release specifications to ensure batch-to-batch consistency and high purity. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity (typically ≥97% by HPLC), and impurity profiles. We operate under a cGMP-compliant quality management system, ensuring traceability and documentation suitable for advanced R&D and pre-clinical development stages.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to the light-sensitive nature and reactive bromomethyl group, it is recommended to store under an inert atmosphere for long-term stability and to minimize potential decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.