Description

6-(2,3-Dihydro-1H-Inden-5-Yl)-4,5-Dihydro-3(2H)-Pyridazinone is a high-purity, advanced pharmaceutical intermediate belonging to the pyridazinone class of heterocyclic compounds. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting cardiovascular and central nervous system disorders. It is primarily utilized by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of new drug candidates, especially PDE (Phosphodiesterase) inhibitors.
• Drug Discovery & Medicinal Chemistry: Serves as a core scaffold for structure-activity relationship (SAR) studies and lead optimization in therapeutic programs.
• Contract Synthesis: Used by CDMOs for the custom synthesis of complex molecules and non-commercial API batches for clinical trials.
• Biochemical Research: Employed as a reference standard or tool compound in pharmacological assays and enzyme inhibition studies.
• Process Chemistry Development: Integral to scaling up and optimizing synthetic routes for potential commercial manufacturing of target APIs.

Basic Information

Product Name	6-(2,3-Dihydro-1H-Inden-5-Yl)-4,5-Dihydro-3(2H)-Pyridazinone
CAS No.	866050-09-1
Molecular Formula	C13H14N2O
Molecular Weight	214.26 g/mol
Synonyms	5-(2,3-Dihydro-1H-inden-5-yl)-4,5-dihydro-3(2H)-pyridazinone; 6-(2,3-Dihydro-1H-inden-5-yl)-2,3,4,5-tetrahydropyridazin-3-one; 5-Indanyl-2-pyridazinone derivative; Indanyl dihydropyridazinone; PDE inhibitor intermediate; CAS 866050-09-1
EINECS	Contact for details

Quality Control

Our 6-(2,3-Dihydro-1H-Inden-5-Yl)-4,5-Dihydro-3(2H)-Pyridazinone is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with each shipment to ensure traceability and compliance with your research or development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.