Description

1-(4-Fluoro-Benzenesulfonyl)-Azetidine-3-Carboxylic Acid is a high-value, multi-functional heterocyclic building block featuring a sulfonamide and a carboxylic acid group. This compound is essential for medicinal chemistry research and development, enabling the synthesis of novel small molecule drug candidates. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers for creating targeted libraries and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of protease inhibitors, kinase inhibitors, and other biologically active molecules targeting various disease pathways.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its versatile azetidine scaffold and modifiable functional groups.
• Chemical Biology Probes: Serves as a core structure for designing chemical probes to study enzyme function and protein-protein interactions.
• Custom Synthesis & Contract Manufacturing: A critical starting material for the custom synthesis of complex, non-commercial compounds for client-specific research programs.
• Library Synthesis: Employed in parallel and combinatorial chemistry to generate diverse compound libraries for high-throughput screening (HTS).

Basic Information

Product Name	1-(4-Fluoro-Benzenesulfonyl)-Azetidine-3-Carboxylic Acid
CAS No.	866043-35-8
Molecular Formula	C10H10FNO4S
Molecular Weight	259.25 g/mol
Synonyms	3-Azetidinecarboxylic acid, 1-[(4-fluorophenyl)sulfonyl]-; 1-(4-Fluorophenylsulfonyl)azetidine-3-carboxylic acid; Azetidine-3-carboxylic acid, 1-(4-fluorobenzenesulfonyl)-; 1-(4-Fluorobenzenesulfonyl)azetidine-3-carboxylic acid; 866043-35-8; 4-Fluoro-N-(3-carboxyazetidin-1-yl)benzenesulfonamide
EINECS	Contact for details

Quality Control

Our production of 1-(4-Fluoro-Benzenesulfonyl)-Azetidine-3-Carboxylic Acid adheres to stringent quality protocols suitable for research and development applications. Each batch undergoes comprehensive analytical characterization, including HPLC for purity, NMR for structural confirmation, and MS for identity verification. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring full traceability and compliance with your internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if specified for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.