Description

[4-(Tetrahydropyran-4-Yloxy)Phenyl]Methylamine is a versatile aromatic amine derivative featuring a tetrahydropyranyloxy substituent, serving as a key chiral building block and intermediate in advanced organic synthesis. Its molecular architecture is critical for introducing specific pharmacophores and modulating physicochemical properties in target molecules. This compound is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex fine chemicals.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of potential drug candidates, particularly for central nervous system (CNS) targets and receptor modulators.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where its structure contributes to biological activity.
• Ligand and Catalyst Development: Serves as a starting material for creating chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the development of advanced polymers and functional materials with specific optical or electronic properties.
• Chemical Biology Probes: Utilized to build molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: A key requested intermediate for custom synthesis projects and scale-up processes under cGMP or ISO standards.

Basic Information

Product Name	[4-(Tetrahydropyran-4-Yloxy)Phenyl]Methylamine
CAS No.	864266-61-5
Molecular Formula	C13H19NO2
Molecular Weight	221.30 g/mol
Synonyms	1-[4-(Oxan-4-yloxy)phenyl]methanamine; 4-[(4-Aminomethyl)phenoxy]tetrahydropyran; (4-(Tetrahydropyran-4-yloxy)phenyl)methanamine; 4-(Tetrahydropyran-4-yloxy)benzylamine; Benzenemethanamine, 4-(tetrahydro-2H-pyran-4-yloxy)-; 4-(Oxan-4-yloxy)benzylamine; TPOPMA (abbreviation); Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our [4-(Tetrahydropyran-4-Yloxy)Phenyl]Methylamine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture. We provide full traceability and Certificates of Analysis (COA) are supplied with every shipment. Specifications can be tailored to meet cGMP, ICH Q7, or other stringent regulatory requirements for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C limits
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.