Description

4-(Chloromethyl)-Tetrahydro-2H-Pyran is a versatile chlorinated heterocyclic building block of significant interest in advanced organic synthesis. Its value lies in the reactive chloromethyl group attached to a tetrahydro-2H-pyran scaffold, enabling its use as a key intermediate for constructing more complex molecular architectures. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for applications in medicinal chemistry and material science.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those containing oxygenated heterocycles.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, where the tetrahydro-2H-pyran moiety can impart favorable biological activity.
• Ligand and Catalyst Development: Acts as a precursor for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Polymer Modification: Employed to introduce functional groups into polymer chains, modifying properties like solubility, adhesion, or reactivity.
• Fine Chemical Production: Utilized in the multi-step synthesis of complex fine chemicals and flavors & fragrances.
• Cross-coupling Reactions: The chloromethyl group can be leveraged in various palladium-catalyzed cross-coupling reactions to form carbon-carbon bonds.

Basic Information

Product Name	4-(Chloromethyl)-Tetrahydro-2H-Pyran
CAS No.	863324-23-6
Molecular Formula	C6H11ClO
Molecular Weight	134.60 g/mol
Synonyms	4-(Chloromethyl)oxane; Tetrahydro-2H-pyran-4-ylmethyl chloride; 4-(Chloromethyl)tetrahydropyran; 4-(Chloromethyl)tetrahydro-2H-pyran; Oxan-4-ylmethyl chloride; 4-Pyranmethanol, tetrahydro-, 4-chloromethyl ether; 863324-23-6
EINECS	Contact for details

Quality Control

Our 4-(Chloromethyl)-Tetrahydro-2H-Pyran is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including chromatography (GC/HPLC) and spectroscopic methods (NMR, IR), to ensure high purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in amber glass or opaque packaging during storage.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.