Description

(1R,1Ar,7Bs)-1,1A,2,7B-Tetrahydrocyclopropa[C]Chromene-1-Carboxylic Acid CAS NO 860265-69-6 is a high-purity, advanced pharmaceutical intermediate characterized by its unique fused cyclopropane-chromene structure. This compound is critical for its role as a sophisticated building block in the synthesis of novel active pharmaceutical ingredients (APIs) and complex organic molecules. It is primarily sought after by research institutions and pharmaceutical manufacturers engaged in drug discovery and process development for therapeutic areas requiring structurally intricate scaffolds.

Application

• Pharmaceutical Intermediate: Serves as a key chiral precursor in the synthesis of proprietary drug candidates and complex target molecules.
• Organic Synthesis Building Block: Used in research-scale and pilot-scale reactions to construct complex polycyclic frameworks for novel material and chemical discovery.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and library synthesis for screening against various biological targets.
• Process Chemistry Development: Utilized in route scouting and optimization for the scalable production of high-value fine chemicals.
• Asymmetric Synthesis: Leverages its defined stereochemistry for the development of enantioselective synthetic pathways.

Basic Information

Product Name	(1R,1Ar,7Bs)-1,1A,2,7B-Tetrahydrocyclopropa[C]Chromene-1-Carboxylic Acid
CAS No.	860265-69-6
Molecular Formula	C12H10O3
Molecular Weight	202.21 g/mol
Synonyms	(1R,1aR,7bS)-1,1a,2,7b-Tetrahydrocyclopropa[c]chromene-1-carboxylic acid; 1,1a,2,7b-Tetrahydrocyclopropa[c]chromene-1-carboxylic acid, (1R,1aR,7bS)-rel-; Cyclopropa[c]chromene-1-carboxylic acid, 1,1a,2,7b-tetrahydro-, (1R,1aR,7bS)-; (1R,1aR,7bS)-rel-1,1a,2,7b-Tetrahydrocyclopropa[c]chromene-1-carboxylic Acid; 860265-69-6; Advanced Chromene-Carboxylic Acid Intermediate
EINECS	Contact for details

Quality Control

Our (1R,1Ar,7Bs)-1,1A,2,7B-Tetrahydrocyclopropa[C]Chromene-1-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Due to its chemical nature, the material should be stored separately from strong bases and oxidizing agents. Keep the container tightly sealed when not in use to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.