Description

(S)-n-(4-Bromobenzylidene)-2-Methylpropane-2-Sulfinamide is a high-purity chiral sulfinamide building block, a key intermediate in asymmetric synthesis. Its value lies in its role as a versatile chiral auxiliary and ligand for the stereoselective construction of complex molecules, particularly in pharmaceutical research. This compound is essential for medicinal chemists and process development scientists in the pharmaceutical and agrochemical industries who require enantiomerically pure intermediates for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: A critical chiral building block for the synthesis of enantiomerically pure drug candidates, particularly in the development of kinase inhibitors and other targeted therapies.
• Asymmetric Synthesis: Used as a chiral auxiliary in the stereoselective addition of nucleophiles to imines (Ellman's sulfinimines), enabling the formation of chiral amines with high enantiomeric excess.
• Ligand Precursor: Serves as a precursor for the synthesis of chiral sulfinamide ligands used in metal-catalyzed asymmetric transformations.
• Agrochemical Research: Employed in the development of novel, enantiomerically pure pesticides and herbicides where specific stereochemistry is crucial for activity and environmental safety.
• Academic & Process Chemistry: A valuable reagent for methodology development in academic laboratories and for scaling up chiral synthetic routes in process chemistry.

Basic Information

Product Name	(S)-n-(4-Bromobenzylidene)-2-Methylpropane-2-Sulfinamide
CAS No.	856562-51-1
Molecular Formula	C11H14BrNOS
Molecular Weight	288.20 g/mol
Synonyms	(S)-N-[(4-Bromophenyl)methylene]-2-methylpropane-2-sulfinamide; (S)-N-(4-Bromobenzylidene)-tert-Butanesulfinamide; (S)-tert-Butanesulfinamide, N-[(4-bromophenyl)methylene]-; (S)-N-(p-Bromobenzylidene)-2-methyl-2-propanesulfinamide; (S)-N-(4-Bromobenzylidene)-2,2-dimethylethanesulfinamide; (S)-Ellman's Sulfinimine (4-Bromo derivative); tert-Butylsulfinyl imine (4-Bromo)
EINECS	Contact for details

Quality Control

Our (S)-n-(4-Bromobenzylidene)-2-Methylpropane-2-Sulfinamide is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high enantiomeric purity. We provide comprehensive analytical data, including HPLC purity and chiral analysis, to support your research and development. Certificates of Analysis (COA) detailing identity, purity, and enantiomeric excess are available upon request for every batch.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is moisture-sensitive; keep the container tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.