Description

2-Benzyl-4-Chloro-5-Trifluoromethanesulfonyloxy-3(2H)-Pyridazinone is a high-value, multi-functional chemical intermediate with a complex heterocyclic structure. Its core value lies in its trifluoromethanesulfonyloxy (triflate) group, which serves as an excellent leaving group, making it a critical building block for advanced organic synthesis, particularly in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce the pyridazinone scaffold into complex molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, cardiovascular diseases, and anti-inflammatory agents.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, leveraging the biological activity of the pyridazinone core.
• Cross-Coupling Reactions: The triflate group acts as a superior electrophile in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille, Negishi) for carbon-carbon bond formation.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Investigated as a monomer or functional additive for creating polymers with specific electronic or photophysical properties.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme function and biological pathways.

Basic Information

Product Name	2-Benzyl-4-Chloro-5-Trifluoromethanesulfonyloxy-3(2H)-Pyridazinone
CAS No.	856250-49-2
Molecular Formula	C₁₃H₁₀ClF₃N₂O₄S
Molecular Weight	382.74 g/mol
Synonyms	2-Benzyl-4-chloro-5-[(trifluoromethyl)sulfonyl]oxy-3(2H)-pyridazinone; 4-Chloro-2-benzyl-5-(trifluoromethanesulfonyloxy)pyridazin-3(2H)-one; 5-(Trifluoromethanesulfonyloxy)-2-benzyl-4-chloro-3(2H)-pyridazinone; 2-Benzyl-4-chloro-5-(triflyloxy)pyridazin-3(2H)-one; 2-Benzyl-4-chloro-5-OTf-3(2H)-pyridazinone; BCTP; CAS 856250-49-2
EINECS	Contact for details

Quality Control

Our 2-Benzyl-4-Chloro-5-Trifluoromethanesulfonyloxy-3(2H)-Pyridazinone is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay (HPLC), identity (NMR, IR), and impurity profiles. Our quality system is designed to meet the stringent requirements of cGMP and ISO standards for advanced chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for prolonged storage or after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure (¹H & ¹³C)
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.