Description

(4R)-6-Methoxycarbonyl-4-Phenyl-3,4-Dihydrocoumarin is a chiral, synthetically valuable dihydrocoumarin derivative. This compound serves as a crucial advanced pharmaceutical intermediate and a versatile building block in organic synthesis. It is primarily required by research institutions and manufacturers in the pharmaceutical and fine chemical industries for developing active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: Key chiral precursor in the synthesis of potential drug candidates, particularly for cardiovascular and central nervous system (CNS) applications.
• Asymmetric Synthesis: Utilized as a building block for constructing complex, enantiomerically pure molecules due to its defined (4R) stereochemistry.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and library synthesis for new therapeutic agents.
• Flavor and Fragrance Industry: Potential intermediate for synthesizing certain lactone-based aroma chemicals.
• Organic Synthesis: Serves as a substrate for various chemical transformations, including ring-opening, reduction, and further functionalization reactions.

Basic Information

Product Name	(4R)-6-Methoxycarbonyl-4-Phenyl-3,4-Dihydrocoumarin
CAS No.	854626-79-2
Molecular Formula	C18H16O4
Molecular Weight	296.32 g/mol
Synonyms	(R)-6-(Methoxycarbonyl)-4-phenyl-3,4-dihydro-2H-chromen-2-one; (4R)-6-(Methoxycarbonyl)-4-phenylchroman-2-one; 4-Phenyl-6-methoxycarbonyl-3,4-dihydrocoumarin, (4R)-; (R)-4-Phenyl-6-(methoxycarbonyl)-3,4-dihydro-2H-1-benzopyran-2-one; 2H-1-Benzopyran-2-one, 6-(methoxycarbonyl)-4-phenyl-3,4-dihydro-, (4R)-; (4R)-6-Carbomethoxy-4-phenyl-3,4-dihydrocoumarin
EINECS	Contact for details

Quality Control

Our (4R)-6-Methoxycarbonyl-4-Phenyl-3,4-Dihydrocoumarin is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and synthesis. Certificates of Analysis (COA) detailing identity, purity, and chiral excess are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat sources and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.