Description

n-[3,5-Bis(Trifluoromethyl)Phenyl]-N'-[(9R)-6'-Methoxycinchonan-9-Yl]- Thiourea is a sophisticated chiral thiourea derivative, recognized as a highly effective organocatalyst and chiral selector. This compound is valued for its ability to facilitate and control asymmetric synthesis, a critical process for producing enantiomerically pure pharmaceuticals and fine chemicals. It is primarily sought by research institutions and industrial chemists in the pharmaceutical, agrochemical, and advanced materials sectors for developing novel synthetic pathways and chiral separations.

Application

• Asymmetric Organocatalysis: Employed as a chiral hydrogen-bond donor catalyst for a variety of enantioselective transformations, including Michael additions, Mannich reactions, and acylations.
• Pharmaceutical Intermediate Synthesis: Used in the research and development of active pharmaceutical ingredients (APIs) requiring high enantiomeric purity.
• Chiral Resolution Agent: Functions as a chiral selector in chromatography or as a resolving agent for the separation of racemic mixtures.
• Ligand in Coordination Chemistry: Can act as a precursor or auxiliary ligand in the synthesis of metal-organic complexes for catalysis.
• Academic & Industrial R&D: A key reagent for methodological studies in organic synthesis and catalysis within university and corporate R&D laboratories.
• Agrochemical Research: Applied in the development of enantiomerically pure herbicides, fungicides, and plant growth regulators.

Basic Information

Product Name	n-[3,5-Bis(Trifluoromethyl)Phenyl]-N'-[(9R)-6'-Methoxycinchonan-9-Yl]- Thiourea
CAS No.	852913-25-8
Molecular Formula	C₃₁H₂₈F₆N₄O₂S
Molecular Weight	634.64 g/mol
Synonyms	(9R)-N-[3,5-Bis(trifluoromethyl)phenyl]-N'-[(6-methoxy-4-quinolyl)methyl]thiocarbamide; Cinchona Alkaloid Thiourea Derivative; (R)-3,5-Bis(trifluoromethyl)phenyl Thiourea of 6'-Methoxycinchonidine; Takemoto Catalyst; Asymmetric Thiourea Organocatalyst; Chiral Bifunctional Thiourea; N-3,5-Bis(trifluoromethyl)phenyl-N'-(6-methoxycinchonan-9-yl)thiourea
EINECS	Contact for details

Quality Control

Every batch of our chiral thiourea catalyst is produced and analyzed under strict quality protocols to ensure high purity and consistent catalytic performance. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as chiral purity (enantiomeric excess), chemical purity (HPLC), and identity confirmation (NMR, IR). Our quality system is designed to meet the rigorous standards of pharmaceutical R&D and process chemistry.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is light-sensitive and should be handled under appropriate conditions to maintain stability and efficacy.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.