Description

Thiourea, n-[3,5-Bis(Trifluoromethyl)Phenyl]-N'-[(8α,9S)-10,11-Dihydro-6'-Methoxycinchonan-9-Yl]- is a sophisticated chiral thiourea derivative, a key class of compounds renowned for their utility as highly effective organocatalysts in asymmetric synthesis. This compound is specifically engineered to provide exceptional enantioselectivity and reaction rate acceleration in a variety of carbon-carbon and carbon-heteroatom bond-forming reactions. It is an essential research and development material for pharmaceutical chemists and process development teams working on the synthesis of chiral active pharmaceutical ingredients (APIs) and other fine chemicals.

Application

• Asymmetric Organocatalysis: Employed as a privileged hydrogen-bond donor catalyst for enantioselective Michael additions, Mannich reactions, and aldol condensations.
• Pharmaceutical Intermediate Synthesis: Critical for constructing chiral centers in the development of novel drug candidates, particularly in medicinal chemistry research.
• Fine Chemical Production: Used in the scalable synthesis of enantiomerically pure flavors, fragrances, and agrochemical intermediates.
• Academic & Industrial R&D: A valuable tool compound for method development in synthetic organic chemistry laboratories.
• Ligand in Metal Complexes: Can act as a chiral ligand precursor for transition metal catalysis, expanding its utility in stereoselective transformations.

Basic Information

Item	Detail
Product Name	Thiourea, n-[3,5-Bis(Trifluoromethyl)Phenyl]-N'-[(8α,9S)-10,11-Dihydro-6'-Methoxycinchonan-9-Yl]-
CAS No.	852913-19-0
Molecular Formula	C₂₉H₂₅F₆N₃OS
Molecular Weight	577.59 g/mol
Synonyms	(8S,9R)-N-[3,5-Bis(trifluoromethyl)phenyl]-N'-[(8α,9S)-10,11-dihydro-6'-methoxycinchonan-9-yl]thiourea; Cinchona Alkaloid-Derived Thiourea Catalyst; (DHQD)₂PYR Thiourea Analogue; Asymmetric Thiourea Organocatalyst; 9-Amino-10,11-dihydrocinchonine Thiourea Derivative; N-(3,5-Bis(trifluoromethyl)phenyl)-N'-((8α,9S)-10,11-dihydro-6'-methoxycinchonan-9-yl)thiourea; Chiral Bifunctional Thiourea
EINECS	Contact for details

Quality Control

Our production of this advanced chiral catalyst adheres to strict quality protocols to ensure batch-to-batch consistency and optimal catalytic performance. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and chiral analysis to confirm chemical identity, high purity, and enantiomeric excess. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after opening to prevent degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.