Description

1-[(S)-1-(Hydroxymethyl)-2,2-Dimethylpropyl]-3-(2,4,6-Trimethylphenyl)-4,5-Dihydro-1H-Imidazolium Hexafluorophosphate is a high-purity, chiral imidazolium salt primarily utilized as a sophisticated catalyst precursor or ligand in advanced organic synthesis. Its value lies in enabling highly selective and efficient chemical transformations, particularly in asymmetric catalysis, which is critical for producing enantiomerically pure intermediates. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and fine chemical industries who require precise stereochemical control in their synthetic routes.

Application

• Asymmetric Catalysis: Serves as a key precursor for generating N-heterocyclic carbene (NHC) catalysts used in enantioselective reactions.
• Pharmaceutical Intermediate Synthesis: Enables the production of chiral active pharmaceutical ingredients (APIs) with high optical purity.
• Organometallic Chemistry: Acts as a ligand for transition metals (e.g., palladium, gold, ruthenium) in cross-coupling and other metal-catalyzed processes.
• Polymerization Catalyst: Used in the development of specialized polymers with controlled microstructures.
• Agrochemical Research: Facilitates the synthesis of novel, stereochemically defined crop protection agents.
• Methodology Development: A valuable tool for academic and industrial research into new catalytic cycles and reaction mechanisms.

Basic Information

Product Name	1-[(S)-1-(Hydroxymethyl)-2,2-Dimethylpropyl]-3-(2,4,6-Trimethylphenyl)-4,5-Dihydro-1H-Imidazolium Hexafluorophosphate
CAS No.	850469-04-4
Molecular Formula	C19H29F6N2O2P
Molecular Weight	486.41 g/mol
Synonyms	(S)-1-(2,4,6-Trimethylphenyl)-3-(2,2-dimethyl-1-(hydroxymethyl)propyl)-4,5-dihydro-1H-imidazol-3-ium hexafluorophosphate; (S)-SIMes·HPF6; (S)-1,3-Bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazolium hexafluorophosphate derivative; Chiral NHC salt precursor; (S)-Hoveyda-type NHC precursor; (S)-IMes·HPF6 analog; (S)-1-(2,2-Dimethyl-1-(hydroxymethyl)propyl)-3-mesityl-4,5-dihydro-1H-imidazol-3-ium hexafluorophosphate
EINECS	Contact for details

Quality Control

Our production of 1-[(S)-1-(Hydroxymethyl)-2,2-Dimethylpropyl]-3-(2,4,6-Trimethylphenyl)-4,5-Dihydro-1H-Imidazolium Hexafluorophosphate adheres to stringent quality protocols to ensure batch-to-batch consistency and high chemical purity. Each lot undergoes comprehensive analysis, including chiral purity verification by HPLC, to meet the exacting standards required for advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening the container for extended periods to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.