Description

(Tetrahydro-Pyran-4-Yl)-Acetonitrile is a versatile nitrile-functionalized heterocyclic building block of significant importance in modern synthetic chemistry. Its value lies in the strategic combination of a stable tetrahydropyran ring and a reactive cyano group, enabling its use as a key intermediate for constructing complex molecular architectures. This compound is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for applications in drug discovery and fine chemical synthesis.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules containing piperidine or tetrahydropyran analogs.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, where the tetrahydropyran moiety can enhance biological activity.
• Ligand and Catalyst Development: Acts as a starting material for creating novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Functional Material Precursor: Employed in the synthesis of advanced polymers and specialty chemicals requiring specific heterocyclic and nitrile functionalities.
• Chemical Biology Probe Synthesis: Useful for constructing molecular probes and tags used in biochemical and medicinal chemistry research.

Basic Information

Product Name	(Tetrahydro-Pyran-4-Yl)-Acetonitrile
CAS No.	850429-50-4
Molecular Formula	C7H11NO
Molecular Weight	125.17 g/mol
Synonyms	4-(Cyanomethyl)tetrahydropyran; 2-(Oxan-4-yl)acetonitrile; Tetrahydro-2H-pyran-4-acetonitrile; (Oxan-4-yl)acetonitrile; (THP-4-yl)acetonitrile; Tetrahydropyran-4-ylacetonitrile; 4-(2-Cyanoethyl)tetrahydropyran (incorrect but common misnomer); 850429-50-4
EINECS	Contact for details

Quality Control

Every batch of (Tetrahydro-Pyran-4-Yl)-Acetonitrile is produced and tested under a strict quality management system. Our products undergo rigorous quality testing, including chromatographic purity analysis and identity confirmation, to ensure compliance with exacting R&D and process chemistry standards. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Refractive Index (n20D)	1.450 - 1.460
Density (g/mL at 20°C)	1.00 - 1.05

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.