Description

Tos-Peg3-T-Butyl Ester CAS NO 850090-13-0 is a specialized bifunctional PEG derivative featuring a tosylate (tosyl) leaving group and a protected tert-butyl ester terminus. This compound is engineered as a versatile building block for the controlled synthesis of complex molecular architectures, particularly in pharmaceutical and bioconjugation chemistry. It is essential for researchers and process chemists in drug discovery, proteomics, and advanced material science who require reliable, high-purity linkers for constructing targeted conjugates and prodrugs.

Application

• Pharmaceutical Linker: A key intermediate for the synthesis of antibody-drug conjugates (ADCs) and other targeted therapeutics, enabling controlled drug attachment.
• Prodrug Synthesis: Used to create cleavable prodrugs where the tert-butyl ester can be deprotected to reveal a carboxylic acid for further coupling or as an active moiety.
• Bioconjugation Reagent: Facilitates the site-specific modification of peptides, proteins, and other biomolecules via the reactive tosylate group.
• Polymer Chemistry: Serves as a functional initiator or monomer in the synthesis of tailored PEG-based polymers and hydrogels with specific end-group functionality.
• Chemical Biology Probes: Employed in the development of molecular probes and diagnostic agents where a hydrophilic PEG spacer is required.
• Material Science: Acts as a surface modifier or crosslinking agent to introduce PEG chains onto materials, enhancing biocompatibility and solubility.

Basic Information

Product Name	Tos-Peg3-T-Butyl Ester
CAS No.	850090-13-0
Molecular Formula	C20H32O8S
Molecular Weight	432.53 g/mol
Synonyms	1,8-Dioxa-14-azaoctadecan-18-oic acid, 14-[[(4-methylphenyl)sulfonyl]oxy]-, 1,1-dimethylethyl ester; tert-Butyl 17-((tosyloxy)methyl)-3,6,9,12-tetraoxa-16-azaheptadecanoate; Tos-PEG3-t-butyl ester; 2,5,8,11-Tetraoxatetradecan-14-oic acid, 14-[[(4-methylphenyl)sulfonyl]oxy]-, 1,1-dimethylethyl ester; PEG3 Tosylate t-Butyl Ester; tert-Butyl-PEG3-OTs; t-Butyl-PEG3-tosylate; 4-Methylbenzenesulfonic acid 3,6,9-trioxa-12-aza-1-(tert-butoxy)-1-oxododec-12-yl ester
EINECS	Contact for details

Quality Control

Our Tos-Peg3-T-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our production adheres to cGMP guidelines where applicable, ensuring consistency and reliability for critical research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Keep the container tightly sealed in a desiccator when not in use.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.