Description

Tos-Peg6-T-Butyl Ester is a specialized bifunctional PEG derivative featuring a tosylate (tosyl) leaving group and a tert-butyl ester protecting group. This compound is a crucial intermediate in organic synthesis and bioconjugation, valued for its role in constructing complex molecules and modifying biomolecules with controlled linker lengths. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors for applications such as prodrug development, peptide synthesis, and the creation of functionalized polymers.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) and prodrugs, utilizing the tosylate group for nucleophilic substitution reactions.
• Bioconjugation & Linker Chemistry: Used to attach drugs, dyes, or other functional groups to proteins, antibodies, or peptides via the hydrophilic PEG6 spacer, improving solubility and pharmacokinetics.
• Polymer & Materials Science: Serves as a monomer or functionalization agent in the synthesis of smart polymers, hydrogels, and surface coatings.
• Protecting Group Strategy: The acid-labile tert-butyl ester group provides orthogonal protection for carboxylic acids during multi-step synthetic sequences.
• Chemical Biology Probes: Facilitates the development of molecular probes and diagnostic agents for research and assay development.
• Cross-linking Agent: Can be employed to create cross-linked networks or dendrimers in advanced material formulations.

Basic Information

Product Name	Tos-Peg6-T-Butyl Ester
CAS No.	850090-10-7
Molecular Formula	C27H48O11S
Molecular Weight	580.74 g/mol
Synonyms	2,5,8,11,14,17-Hexaoxanonadecan-19-yl 4-methylbenzenesulfonate, tert-butyl ester; tert-Butyl-PEG6-tosylate; Tos-PEG6-OtBu; 4-Methylbenzenesulfonic acid 2,5,8,11,14,17-hexaoxanonadecan-19-yl ester, 1,1-dimethylethyl ester; PEG6 Tosylate tert-Butyl Ester; t-Butyl-PEG6-OTs; Tosylate-PEG6-t-butyl ester; Tosylated Hexaethylene Glycol tert-Butyl Ether
EINECS	Contact for details

Quality Control

Our Tos-Peg6-T-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Keep container tightly sealed in a desiccated environment.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.