Description

n-Boc-1-Methylcyclopropane-1-Sulfonamide is a high-purity, advanced pharmaceutical intermediate featuring a unique cyclopropane-sulfonamide scaffold protected by a tert-butoxycarbonyl (Boc) group. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of novel drug candidates with enhanced metabolic stability and targeted biological activity. It is primarily needed by R&D scientists and process chemists in the pharmaceutical and biotechnology industries for the development of new therapeutic agents, particularly in areas like enzyme inhibition and targeted protein degradation.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new active pharmaceutical ingredients (APIs), especially for protease inhibitors and other small-molecule therapeutics.
• Proteolysis-Targeting Chimera (PROTAC) Linker: Serves as a specialized component in the design of PROTAC molecules, connecting the target protein binder to the E3 ligase recruiter.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore and optimize the physicochemical and pharmacological properties of lead compounds.
• Process Chemistry & Scale-Up: Employed in route scouting and optimization for the scalable synthesis of complex drug molecules under GMP-like conditions.
• Chemical Biology Tool: Utilized in the development of chemical probes for studying enzyme function and cellular pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds and reference standards for clinical trials.

Basic Information

Product Name	n-Boc-1-Methylcyclopropane-1-Sulfonamide
CAS No.	849022-29-3
Molecular Formula	C9H17NO4S
Molecular Weight	235.30 g/mol
Synonyms	1-Methylcyclopropanesulfonamide, N-BOC derivative; tert-Butyl (1-methylcyclopropyl)sulfonylcarbamate; N-(tert-Butoxycarbonyl)-1-methylcyclopropane-1-sulfonamide; 1-Methyl-1-(N-Boc-sulfamoyl)cyclopropane; Boc-1-Methylcyclopropanesulfonamide; (1-Methylcyclopropyl)sulfonylcarbamic acid tert-butyl ester; N-Boc-1-Methylcyclopropanesulfonamide
EINECS	Contact for details

Quality Control

Our n-Boc-1-Methylcyclopropane-1-Sulfonamide is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure it meets the high-purity standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing purity, identity, and impurity profiles as determined by techniques such as HPLC, NMR, and mass spectrometry.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.