Description

4-Ethyl-7-Methyl-5-(1H-Tetrazol-5-Ylmethoxy)-2H-Chromen-2-One CAS NO 848986-52-7 is a high-purity, advanced pharmaceutical intermediate characterized by its unique chromen-2-one (coumarin) core functionalized with a tetrazole moiety. This compound is of significant commercial interest due to its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily sought after by research institutions and pharmaceutical manufacturers engaged in the development of new therapeutic agents, particularly in areas requiring complex heterocyclic chemistry.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of new drug candidates, especially those targeting cardiovascular and metabolic diseases.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• API Synthesis: Used in the multi-step synthesis of complex target molecules where the coumarin-tetrazole hybrid structure is integral to biological activity.
• Biochemical Probe Development: Employed in the design and creation of molecular probes for studying enzyme inhibition and receptor binding.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP production of clinical trial materials.

Basic Information

Product Name	4-Ethyl-7-Methyl-5-(1H-Tetrazol-5-Ylmethoxy)-2H-Chromen-2-One
CAS No.	848986-52-7
Molecular Formula	C₁₄H₁₄N₄O₃
Molecular Weight	286.29 g/mol
Synonyms	5-[(4-Ethyl-7-methyl-2-oxo-2H-chromen-5-yl)oxy]-1H-tetrazole; 4-Ethyl-7-methyl-5-(1H-tetrazol-5-ylmethoxy)coumarin; 4-Ethyl-7-methyl-5-(tetrazol-5-ylmethoxy)-2H-chromen-2-one; 848986-52-7; 5-(4-Ethyl-7-methyl-2-oxochromen-5-yloxy)-1H-tetrazole; Tetrazole-substituted coumarin derivative
EINECS	Contact for details

Quality Control

Our production of 4-Ethyl-7-Methyl-5-(1H-Tetrazol-5-Ylmethoxy)-2H-Chromen-2-One adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. All material is released only after passing comprehensive analytical testing, including HPLC for purity and identity confirmation. Certificates of Analysis (COA) detailing all test results are provided with each shipment. We support development and commercial projects requiring compliance with cGMP guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (typically 15-25°C). The compound may be light-sensitive; prolonged exposure to light should be avoided. Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.