Description

4-Cyano-Tetrahydropyran-4-Carboxylic Acid is a versatile heterocyclic building block featuring both cyano and carboxylic acid functional groups on the same carbon atom. This unique bifunctional structure makes it a critical intermediate for the synthesis of complex molecules in advanced pharmaceutical and agrochemical research. It is primarily sought after by R&D chemists and process development scientists working on novel active ingredients, particularly in medicinal chemistry for creating constrained analogs and fused ring systems.

Application

• Pharmaceutical Intermediate: Key synthon for the development of protease inhibitors, kinase inhibitors, and other small molecule therapeutics.
• Agrochemical Synthesis: Building block for novel herbicides, fungicides, and insecticides requiring specific spatial and electronic properties.
• Chemical Biology & Proteomics: Used in the design of activity-based probes and molecular tags due to its reactive handles.
• Material Science Research: Precursor for specialty polymers and functionalized materials with tailored properties.
• Academic & Contract Research: Serves as a valuable starting material in method development and novel synthetic route exploration.

Basic Information

Product Name	4-Cyano-Tetrahydropyran-4-Carboxylic Acid
CAS No.	848821-06-7
Molecular Formula	C8H9NO3
Molecular Weight	167.16 g/mol
Synonyms	4-Cyanooxane-4-carboxylic acid; Tetrahydropyran-4-carbonitrile-4-carboxylic acid; 4-Carboxy-4-cyanotetrahydropyran; 4-Cyano-4-carboxytetrahydropyran; 4-Cyano-4-tetrahydropyrancarboxylic acid; 4-Cyano-THP-4-carboxylic acid; 4-CN-THP-4-COOH; 848821-06-7
EINECS	Contact for details

Quality Control

Our 4-Cyano-Tetrahydropyran-4-Carboxylic Acid is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and KF titration for moisture content, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with full traceability are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.