Description

3-(Dimethylphenylsilyl)-Cyclobutanone is a specialized organosilicon building block featuring a cyclobutanone ring functionalized with a dimethylphenylsilyl group. This compound matters as a versatile intermediate for advanced organic synthesis, particularly in the construction of complex molecular architectures for pharmaceuticals and materials science. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for applications in cross-coupling reactions, ring-expansion chemistry, and as a precursor to novel silicon-containing compounds.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for ring-based scaffolds.
• Agrochemical Synthesis: Used in the creation of novel herbicides, fungicides, and insecticides where the silicon moiety can influence bioavailability and stability.
• Advanced Material Precursor: Acts as a monomer or cross-linking agent in the synthesis of specialty polymers, resins, and silicon-based hybrid materials.
• Organic Synthesis Building Block: Employed in palladium-catalyzed cross-coupling reactions (e.g., Hiyama coupling) and other transition metal-mediated transformations.
• Ligand and Catalyst Development: Utilized for the preparation of novel silicon-containing ligands for asymmetric catalysis and organometallic complexes.
• Academic and Industrial R&D: A valuable reagent for methodological studies in synthetic organic chemistry, exploring new reaction pathways involving strained rings.

Basic Information

Product Name	3-(Dimethylphenylsilyl)-Cyclobutanone
CAS No.	847158-84-3
Molecular Formula	C12H16OSi
Molecular Weight	204.34 g/mol
Synonyms	Cyclobutanone, 3-(dimethylphenylsilyl)-; 3-(Dimethylphenylsilyl)cyclobutanone; 3-(Phenyldimethylsilyl)cyclobutanone; Dimethyl(phenyl)silylcyclobutanone; (Dimethylphenylsilyl)cyclobutanone
EINECS	Contact for details

Quality Control

Our 3-(Dimethylphenylsilyl)-Cyclobutanone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR, GC, and HPLC, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment to guarantee compliance with your research and production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. For long-term storage, it is recommended to keep the material under an inert atmosphere (e.g., nitrogen or argon) at temperatures between 2°C and 8°C to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 95.0%
Purity (HPLC)	≥ 95.0%
Water Content	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.