Description

Toluene-4-Sulfonic Acid 1-Acetyl-Piperidin-4-Ylmethyl Ester is a specialized organic building block and intermediate of significant interest in advanced synthetic chemistry. This compound matters for its role as a key precursor in the development of complex pharmacologically active molecules, offering a versatile chemical handle for further functionalization. It is primarily needed by research institutions and pharmaceutical companies engaged in the synthesis of novel drug candidates, particularly within medicinal chemistry programs targeting central nervous system (CNS) and other therapeutic areas.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the multi-step synthesis of potential drug candidates and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new therapeutic agents.
• Chemical Synthesis: Acts as a versatile intermediate for introducing the 1-acetyl-piperidin-4-ylmethyl moiety into more complex molecular architectures.
• Academic & R&D Laboratories: Employed in exploratory organic synthesis and the development of novel synthetic methodologies.
• Pre-clinical Development: Utilized for producing compounds required for pharmacological screening and early-stage toxicology studies.

Basic Information

Product Name	Toluene-4-Sulfonic Acid 1-Acetyl-Piperidin-4-Ylmethyl Ester
CAS No.	846057-25-8
Molecular Formula	C16H23NO4S
Molecular Weight	325.42 g/mol
Synonyms	1-Acetyl-4-[(4-methylphenyl)sulfonyloxymethyl]piperidine; 4-Methylbenzenesulfonic Acid 1-Acetyl-4-piperidinylmethyl Ester; 1-Acetyl-4-[(p-toluenesulfonyloxy)methyl]piperidine; p-Toluenesulfonic Acid 1-Acetylpiperidin-4-ylmethyl Ester; 4-(Acetylpiperidinyl)methyl Tosylate; (1-Acetylpiperidin-4-yl)methyl 4-methylbenzenesulfonate; Tosyloxy Derivative of 1-Acetyl-4-piperidinemethanol
EINECS	Contact for details

Quality Control

Our Toluene-4-Sulfonic Acid 1-Acetyl-Piperidin-4-Ylmethyl Ester is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.