Description

1-(Trimethylsilyl)-3-Chloro-4-Fluorobenzene is a high-purity organosilicon intermediate featuring a unique halogenated aromatic structure. This compound is valued for its role as a versatile building block in advanced organic synthesis, particularly in the development of pharmaceuticals and agrochemicals. It is essential for researchers and manufacturers in fine chemical, pharmaceutical R&D, and material science sectors requiring precise functionalization of aromatic systems.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), especially those requiring halogenated and silyl-protected aromatic motifs.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides where the chloro-fluoro substitution pattern is critical for bioactivity.
• Liquid Crystal & OLED Materials: Serves as a precursor in the manufacture of specialty chemicals for electronic displays and organic light-emitting diodes (OLEDs).
• Cross-Coupling Reactions: An effective substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) for constructing complex biaryl systems.
• Protecting Group Chemistry: The trimethylsilyl group can act as a protective moiety for hydroxyl or other functional groups in multi-step synthetic pathways.
• Material Science Research: Employed in the development of novel polymers, ligands for catalysis, and other functional materials.

Basic Information

Product Name	1-(Trimethylsilyl)-3-Chloro-4-Fluorobenzene
CAS No.	845823-20-3
Molecular Formula	C9H12ClFSi
Molecular Weight	202.73 g/mol
Synonyms	3-Chloro-4-fluoro(trimethylsilyl)benzene; (3-Chloro-4-fluorophenyl)trimethylsilane; Trimethyl(3-chloro-4-fluorophenyl)silane; 1-Chloro-2-fluoro-4-(trimethylsilyl)benzene; 3-Chloro-4-fluorophenyltrimethylsilane; 845823-20-3; Benzene, 1-(trimethylsilyl)-3-chloro-4-fluoro-
EINECS	Contact for details

Quality Control

Our 1-(Trimethylsilyl)-3-Chloro-4-Fluorobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high chemical purity and identity. Certificates of Analysis (COA) detailing purity, impurity profile, and physical characteristics are provided with every shipment to guarantee consistent quality and traceability for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC)	Individual impurity ≤ 1.0%
Total Impurities	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.