Description

3-Benzyl-6-Chloro-9-(4-Fluorophenyl)-4-Methyl-8,10-Dihydropyrano[2,3-F][1,3]Benzoxazin-2-One CAS NO 844456-18-4 is a high-purity, complex heterocyclic organic compound belonging to the benzoxazinone class. This advanced pharmaceutical intermediate is valued for its precise molecular architecture, which is critical for the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily sought by research institutions and pharmaceutical manufacturers engaged in the development of new therapeutic agents, particularly within medicinal chemistry and process R&D.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel drug candidates, particularly for central nervous system (CNS) and anti-inflammatory targets.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Process Development: Employed in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales.
• Custom Synthesis: A starting material for the preparation of more complex, proprietary molecules under contract research and manufacturing (CRAM) agreements.
• Reference Standard: Utilized as an analytical standard for quality control and method validation in API production.

Basic Information

Product Name	3-Benzyl-6-Chloro-9-(4-Fluorophenyl)-4-Methyl-8,10-Dihydropyrano[2,3-F][1,3]Benzoxazin-2-One
CAS No.	844456-18-4
Molecular Formula	C26H19ClFNO3
Molecular Weight	447.89 g/mol
Synonyms	3-Benzyl-6-chloro-9-(4-fluorophenyl)-4-methyl-8,10-dihydropyrano[2,3-f][1,3]benzoxazin-2-one; 8,10-Dihydropyrano[2,3-f][1,3]benzoxazin-2-one, 3-(phenylmethyl)-6-chloro-9-(4-fluorophenyl)-4-methyl-; 844456-18-4; Benzoxazinone derivative; Pyranobenzoxazinone intermediate
EINECS	Contact for details

Quality Control

Our production of 3-Benzyl-6-Chloro-9-(4-Fluorophenyl)-4-Methyl-8,10-Dihydropyrano[2,3-F][1,3]Benzoxazin-2-One adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and MS, to ensure it meets the exacting standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents. For long-term storage, consider an inert atmosphere to preserve stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.