Description

4,4-Difluoro-1-(5-Methyl-Thiophen-2-Yl)-Butane-1,3-Dione is a specialized fluorinated diketone building block of significant interest in advanced organic synthesis. Its core value lies in its unique molecular architecture, which combines a reactive 1,3-diketone moiety with a fluorinated alkyl chain and a thiophene heterocycle, enabling precise molecular modifications. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, where it serves as a key intermediate for developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of complex drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used to construct novel active molecules for crop protection agents, leveraging the fluorine atoms to enhance biological activity and environmental stability.
• Material Science Research: Serves as a building block for developing advanced organic electronic materials, such as semiconductors and light-emitting components, due to the conjugated thiophene system.
• Ligand and Catalyst Development: The 1,3-diketone functionality makes it a valuable starting material for creating chelating ligands used in catalysis and metal-organic frameworks (MOFs).
• Fluorine Chemistry Studies: An important substrate for investigating new fluorination reactions and studying the effects of fluorine substitution on molecular properties.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds for client R&D programs.

Basic Information

Item	Details
Product Name	4,4-Difluoro-1-(5-Methyl-Thiophen-2-Yl)-Butane-1,3-Dione
CAS No.	832737-14-1
Molecular Formula	C9H8F2O2S
Molecular Weight	218.22 g/mol
Synonyms	1-(5-Methyl-2-thienyl)-4,4-difluoro-1,3-butanedione; 4,4-Difluoro-1-(5-methyl-2-thienyl)-1,3-butanedione; 4,4-Difluoro-1-(5-methylthiophen-2-yl)butane-1,3-dione; 5-Methyl-2-thenoylacetone, difluoro derivative; 2-Thiophenebutanedione, 4,4-difluoro-1-(5-methyl-2-thienyl)-; Fluorinated thiophene diketone; Difluorinated β-diketone thiophene derivative
EINECS	Contact for details

Quality Control

Our 4,4-Difluoro-1-(5-Methyl-Thiophen-2-Yl)-Butane-1,3-Dione is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles where applicable, ensuring the material meets the exacting standards for research and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.